Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.
Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.
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DOI：
10.1177/0269881117728429
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Simmons WK
中科院分区：
文献类型：
--
作者：
Avery JA;Powell JN;Breslin FJ;Lepping RJ;Martin LE;Patrician TM;Donnelly JE;Savage CR;Simmons WK
肥胖从根本上说是一种能量平衡失调。在肥胖个体中，消耗的能量多于消耗的能量，导致通过脂肪组织的积累而过度增重。由肥胖引起的并发症，包括心血管疾病、外周炎症升高和II型糖尿病的发展，使肥胖成为发病率和死亡率的主要可预防原因之一。因此，了解能量平衡行为调节的神经回路对个人和公共健康都至关重要。为此，我们试图研究与肥胖相关的差异，在静息状态下的功能连接的背正中，味觉和内感受皮层的区域与稳态敏感的反应，食物刺激。在本研究中，肥胖和健康体重的个体在不同的内感受性状态下完成静息fMRI扫描，无论是空腹还是标准餐后。我们研究了餐前与餐后中脑功能连接的组间差异，以及这些差异如何与自我报告的饥饿评分和用餐愉快度评分的差异相关。肥胖和健康体重的个体表现出相反的模式之间的背中-背侧和多个大脑区域参与奖励，评价和饱腹感，包括内侧眶额皮质，背侧纹状体，腹侧纹状体的进食相关的功能连接。特别是，健康体重的参与者表现出显着的正相关关系的变化，饥饿和内侧眶额功能连接的变化，而肥胖的参与者表现出互补的负相关关系的饥饿和腹侧纹状体连接到中间的。这些与肥胖相关的背正中神经功能连接模式的改变可能意味着肥胖个体的食物动机体验的根本差异，其中对食物的接近行为更多地由寻求奖励而不是由来自身体的稳态相关内感受信息引导。
Obesity is fundamentally a disorder of energy balance. In obese individuals, more energy is consumed than is expended, leading to excessive weight gain through the accumulation of adipose tissue. Complications arising from obesity, including cardiovascular disease, elevated peripheral inflammation, and the development of Type II diabetes, make obesity one of the leading preventable causes of morbidity and mortality. Thus it is of paramount importance to both individual and public health that we understand the neural circuitry underlying the behavioral regulation of energy balance. To this end, we sought to examine obesity-related differences in the resting state functional connectivity of the dorsal mid-insula, a region of gustatory and interoceptive cortex associated with homeostatically-sensitive responses to food stimuli. Within the present study, obese and healthy weight individuals completed resting fMRI scans during varying interoceptive states, both while fasting and after a standardized meal. We examined group differences in the pre vs. post-meal functional connectivity of the mid-insula, and how those differences were related to differences in self-reported hunger ratings and ratings of meal pleasantness. Obese and healthy weight individuals exhibited opposing patterns of eating-related functional connectivity between the dorsal mid-insula and multiple brain regions involved in reward, valuation, and satiety, including the medial orbitofrontal cortex, the dorsal striatum, and the ventral striatum. In particular, healthy weight participants exhibited a significant positive relationship between changes in hunger and changes in medial orbitofrontal functional connectivity, while obese participants exhibited a complementary negative relationship between hunger and ventral striatum connectivity to the mid-insula. These obesity-related alterations in dorsal mid-insula functional connectivity patterns may signify a fundamental difference in the experience of food motivation in obese individuals, wherein approach behavior toward food is guided more by reward-seeking than by homeostatically-relevant interoceptive information from the body.
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影响因子：
5.7
作者：
Holsen, LM;Zarcone, JR;Savage, CR
通讯作者：
Savage, CR
影响因子：
11
作者：
Guo, J.;Simmons, W. K.;Herscovitch, P.;Martin, A.;Hall, K. D.
通讯作者：
Hall, K. D.
人背侧互联网中的收敛性和内脏感应。
影响因子：
4.8
作者：
Avery JA;Gotts SJ;Kerr KL;Burrows K;Ingeholm JE;Bodurka J;Martin A;Kyle Simmons W
通讯作者：
Kyle Simmons W
DOI：
10.1038/nrn3950
发表时间：
2015-07
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Barrett LF;Simmons WK
通讯作者：
Simmons WK
影响因子：
29
作者：
Malik, Saima;McGlone, Francis;Dagher, Alain
通讯作者：
Dagher, Alain