Renal BOLD-MRI relates to kidney function and activity of the renin–angiotensin–aldosterone system in hypertensive patients
Renal BOLD-MRI relates to kidney function and activity of the renin–angiotensin–aldosterone system in hypertensive patients
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肾脏 BOLD-MRI 与高血压患者的肾功能和肾素-血管紧张素-醛固酮系统活性相关
DOI：
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发表时间：
2015
影响因子：
4.9
通讯作者：
P. Blankestijn
中科院分区：
文献类型：
--
作者：
E. Vink;Anneloes de Boer;H. Hoogduin;M. Voskuil;T. Leiner;M. Bots;J. Joles;P. Blankestijn
背景：肾素-血管紧张素-醛固酮系统（RAAS）和交感神经系统是高血压病理生理过程中的关键因素。肾缺氧是刺激这两个系统的假定机制。血氧水平依赖性MRI（BOLD-MRI）提供了一种非侵入性的工具，以确定人体肾脏氧合。本研究的目的是探讨血压（BP）与肾脏BOLD-MRI肾功能之间的关系。此外，研究了RAAS的直接和间接变量与交感神经系统和肾脏BOLD-MRI之间的关系。方法：75例高血压患者（男性38例）。暂时停用抗高血压药物。患者在24小时内收集尿液（钠、儿茶酚胺），采集血液样本（肌酸酐、血浆蛋白酶、醛固酮），进行巯甲丙脯酸激发试验，并测量动态血压。 结果：平均年龄为58（±11）岁，日间血压为167（±19）/102（±16）mmHg，估计肾小球滤过率为75（±18）ml/min/1.73 m2。 在多变量回归分析中，肾髓质R2* 值与估计的肾小球滤过率呈负相关（P = 0.02）。 此外，卡托普利的降压作用与皮质（P = 0.02）和髓质（P = 0.008）R2* 值以及P90（P = 0.02）呈正相关。 结论：在高血压患者中，肾功能与髓质R2* 值有关。RAAS的激活也与肾脏R2* 值呈正相关。
Background: The renin–angiotensin–aldosterone system (RAAS) and the sympathetic nervous system are key factors in the pathophysiology of hypertension. Renal hypoxia is the putative mechanism stimulating both systems. Blood oxygen level-dependent MRI (BOLD-MRI) provides a noninvasive tool to determine renal oxygenation in humans. The aim of the current study was to investigate the relation between blood pressure (BP) and kidney function with renal BOLD-MRI. Moreover, the relation between direct and indirect variables of the RAAS and sympathetic nervous system and renal BOLD-MRI was studied. Method: Seventy-five hypertensive patients (38 men) were included. Antihypertensive medication was temporarily stopped. Patients collected urine during 24 h (sodium, catecholamines), blood samples were taken (creatinine, renin, aldosterone), a captopril challenge test was performed, and ambulatory BP was measured. Results: Mean age was 58 (±11) years, day-time BP was 167 (±19)/102 (±16) mmHg, and estimated glomerular filtration rate was 75 (±18) ml/min per 1.73 m2). In multivariable regression analysis, renal medullary R2*-values inversely related to estimated glomerular filtration rate (P = 0.02). Moreover, the BP-lowering effect of captopril positively related to cortical (P = 0.02) and medullary (P = 0.008) R2*-values, as well as to P90 (P = 0.02). Conclusion: In patients with hypertension, kidney function relates to medullary R2*-values. Activation of the RAAS is also positively related to the renal R2*-values.
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影响因子：
19.6
作者：
Michaely, Henrik J.;Metzger, Linda;Attenberger, Ulrike I.
通讯作者：
Attenberger, Ulrike I.
DOI：
10.1161/hypertensionaha.107.092858
发表时间：
2008-11
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cowley AW Jr
通讯作者：
Cowley AW Jr
DOI：
10.1016/j.mric.2008.07.008
发表时间：
2008-11
影响因子：
1.6
作者：
Li, Lu-Ping;Halter, Sarah;Prasad, Pottumarthi V.
通讯作者：
Prasad, Pottumarthi V.
影响因子：
16.2
作者：
Epstein, FH;Veves, A;Prasad, PV
通讯作者：
Prasad, PV
有限的肾损伤可能会导致永久性的神经源性高血压。
影响因子：
3.2
作者：
Ye,S;Gamburd,M;Mozayeni,P;Koss,M;Campese,VM
通讯作者：
Campese,VM