odd-skipped genes and lines organize the notum anterior-posterior axis using autonomous and non-autonomous mechanisms.
odd-skipped genes and lines organize the notum anterior-posterior axis using autonomous and non-autonomous mechanisms.
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DOI：
10.1016/j.mod.2012.05.001
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发表时间：
2012-07
影响因子：
2.6
通讯作者：
Hatini, Victor
中科院分区：
文献类型：
--
作者：
Del Signore, Steven J.;Hayashi, Teru;Hatini, Victor
果蝇翅原基和背原基的生长和图案化依赖于它们被称为组织者的局部来源发出的分泌信号细分为逐渐变小的结构域。虽然组织翅原基的机制已被广泛研究，那些组织背是不完全理解。奇跳基因（odd-skipped）、鼓槌基因（drumstick）、sob基因和bowl基因组成了奇跳C2 H2锌指基因家族，该家族与背的生长和图案形成有关。在这里，我们表明，nerve，碗，和eyegone（eyg），一个基因所需的背图案，积累在巢状结构域中的前背。异位卵巢组织了这些前背基因的巢状表达，下调了后背基因的表达。Bowl和Eyg的细胞自主诱导需要Bowl，而非自主效应不依赖于Bowl。同源结构域蛋白Bar沿着与表达Notch（N）配体Delta（D1）的细胞相邻的背的前边界表达。需要碗来促进Bar和抑制Dl表达，以细胞自主的方式形成前背图案，而线则拮抗地作用于碗结构域后面的碗。我们的数据表明，奇跳基因的行为在前背边界组织背前后（AP）轴使用自主和非自主机制。
The growth and patterning of Drosophila wing and notum primordia depend on their subdivision into progressively smaller domains by secreted signals that emanate from localized sources termed organizers. While the mechanisms that organize the wing primordium have been studied extensively, those that organize the notum are incompletely understood. The genes odd-skipped (odd), drumstick (drm), sob, and bowl comprise the odd-skipped family of C2H2 zinc finger genes, which has been implicated in notum growth and patterning. Here we show that drm, Bowl, and eyegone (eyg), a gene required for notum patterning, accumulate in nested domains in the anterior notum. Ectopic drm organized the nested expression of these anterior notum genes and downregulated the expression of posterior notum genes. The cell autonomous induction of Bowl and Eyg required bowl, while the non-autonomous effects were independent of bowl. The homeodomain protein Bar is expressed along the anterior border of the notum adjacent to cells expressing the Notch (N) ligand Delta (Dl). bowl was required to promote Bar and repress Dl expression to pattern the anterior notum in a cell-autonomous manner, while lines acted antagonistically to bowl posterior to the Bowl domain. Our data suggest that the odd-skipped genes act at the anterior notum border to organize the notum anterior-posterior (AP) axis using both autonomous and non-autonomous mechanisms.
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