Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study.
Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study.
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DOI：
10.1016/j.jacc.2009.03.026
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发表时间：
2009-06-16
影响因子：
24
通讯作者：
Davis, Patricia H.
中科院分区：
文献类型：
--
作者：
Dawson, Jeffrey D.;Sonka, Milan;Blecha, Mary Beth;Lin, Wenjiao;Davis, Patricia H.
确定心血管危险因素是否与青少年和年轻人的主动脉和颈动脉内膜中层厚度（aIMT和cIMT）相关。动脉粥样硬化病变开始发展在青年，首先在远端腹主动脉，后来在颈动脉。了解危险因素与aIMT和cIMT的关系可能有助于设计预防心血管疾病的早期干预措施。参与者是马斯卡廷后代队列的635名成员。使用自动阅读程序测量平均aIMT和cIMT。aIMT和cIMT的平均值（SD）分别为0.63（0.14）mm和0.49（0.04）mm。在青少年（11 - 17岁）中，校正年龄、性别和身高后，aIMT与甘油三酯、收缩压（SBP）、舒张压（DBP）、体重指数（BMI）和腰臀比相关。在年轻人（18至34岁）中，aIMT与同样的五个风险因素以及HDL-胆固醇和脉压相关。在青少年中，cIMT与SBP、脉压、心率、BMI和腰臀比相关。在年轻成人中，cIMT与总胆固醇、LDL-胆固醇、甘油三酯、SBP、DBP、BMI、腰/臀比和HbA 1C相关。在两个年龄组中，aIMT和cIMT与PDAY冠状动脉风险评分显著相关。aIMT和cIMT均与心血管危险因素相关。在青少年中使用aIMT提供的信息超出了单独从cIMT获得的信息。测量aIMT和cIMT可能有助于识别早发心血管疾病的风险。
To determine whether cardiovascular risk factors are associated with aortic and carotid intimal-medial thickness (aIMT and cIMT) in adolescents and young adults. Atherosclerotic lesions begin developing in youth, first in the distal abdominal aorta and later in the carotid arteries. Knowledge of how risk factors relate to aIMT and cIMT may help in the design of early interventions to prevent cardiovascular disease. Participants were 635 members of the Muscatine Offspring cohort. The mean aIMT and cIMT were measured using an automated reading program. The means (SDs) of aIMT and cIMT were 0.63 (0.14) mm and 0.49 (0.04) mm, respectively. In adolescents (ages 11 to 17), aIMT was associated with triglycerides, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and waist/hip ratio, after adjusting for age, gender, and height. In young adults (ages 18 to 34), aIMT was associated with those same five risk factors, plus HDL-cholesterol and pulse pressure. In adolescents, cIMT was associated with SBP, pulse pressure, heart rate, BMI, and waist/hip ratio. In young adults, cIMT was associated total cholesterol, LDL-cholesterol, triglycerides, SBP, .DBP, BMI, waist/hip ratio, and HbA1C. In both age groups, aIMT and cIMT were significantly correlated with the PDAY coronary artery risk score. Both aIMT and cIMT are associated with cardiovascular risk factors. Using aIMT in adolescents gives information beyond that obtained from cIMT alone. Measurement of aIMT and cIMT may help identify those at risk for premature cardiovascular disease.
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影响因子：
1.5
作者：
Ishizu, T;Ishimitsu, T;Yamaguchi, I
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