Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea.
Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea.
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DOI：
10.1097/wnr.0000000000001971
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发表时间：
2024-01-03
期刊：
影响因子：
1.7
通讯作者：
中科院分区：
文献类型：
--
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神经影像学研究表明认知控制网络（CCN）与慢性疼痛的维持有关。然而，作为CCN内的一个关键区域，背外侧前额叶皮层（DLPFC）是否以及如何在月经疼痛中发生改变尚不清楚。在这项研究中，我们旨在研究原发性痛经（PDM）患者DLPFC功能连接网络的改变。该研究包括41名PDM患者和39名匹配的健康对照（hc），他们都在月经期接受了静息状态功能MRI扫描。所有参与者在MRI扫描前完成临床评估。我们使用DLPFC作为静息状态功能连接（rsFC）分析的种子来研究PDM患者和hc患者之间的差异。与正常人相比，PDM患者在双侧舌回、背前扣带皮层（dACC）和中扣带皮层的右侧DLPFC rsFC增加，而在右侧眶额皮层的左侧DLPFC rsFC减少。此外，PDM患者右侧dlpfc -双侧dACC连通性增加介导了疾病持续时间与自评焦虑量表（SAS）评分之间的关联。我们证实DLPFC-dACC rsFC与较高的SAS评分相关，这可能介导PDM患者疾病持续时间与焦虑症状之间的关联。我们的研究结果为PDM患者CCN rsFC异常提供了核心病理证据，这可能有助于更好地理解PDM的神经病理生理机制。
Neuroimaging studies have demonstrated the association of the cognitive control network (CCN) with the maintenance of chronic pain. However, whether and how dorsolateral prefrontal cortex (DLPFC), a key region within the CCN, is altered in menstrual pain is unclear. In this study, we aimed to investigate alterations in the DLPFC functional connectivity network in patients with primary dysmenorrhea (PDM). The study comprised 41 PDM patients and 39 matched healthy controls (HCs), all of whom underwent a resting-state functional MRI scan during the menstrual stage. All participants were instructed to complete the clinical assessment before the MRI scan. We used the DLPFC as the seed in resting-state functional connectivity (rsFC) analysis to investigate the difference between PDM patients and HCs. Compared to HCs, PDM patients showed increased right DLPFC rsFC at the bilateral lingual gyrus, dorsal anterior cingulate cortex (dACC), and middle cingulate cortex, and decreased left DLPFC rsFC at the right orbital frontal cortex. In addition, increased right DLPFC-bilateral dACC connectivity mediated the association between disease duration and the self-rating anxiety scale (SAS) scores in PDM patients. We confirmed that the DLPFC-dACC rsFC was associated with higher SAS scores, which could mediate the association between disease duration and anxiety symptoms in patients with PDM. Our findings provide central pathological evidence for an abnormal rsFC of the CCN in PDM patients, which may contribute to a better understanding of the neuropathophysiological mechanisms underlying PDM.
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DOI：
10.3758/s13415-018-0564-x
发表时间：
2018-04
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Lopez KC;Luby JL;Belden AC;Barch DM
通讯作者：
Barch DM
影响因子：
3.7
作者：
Lee LC;Tu CH;Chen LF;Shen HD;Chao HT;Lin MW;Hsieh JC
通讯作者：
Hsieh JC
影响因子：
3.2
作者：
Kong J;Wolcott E;Wang Z;Jorgenson K;Harvey WF;Tao J;Rones R;Wang C
通讯作者：
Wang C
影响因子：
4.1
作者：
通讯作者：
--
DOI：
10.1186/s10194-021-01259-x
发表时间：
2021-05-21
期刊：
The journal of headache and pain
影响因子：
--
作者：
Wei HL;Li J;Guo X;Zhou GP;Wang JJ;Chen YC;Yu YS;Yin X;Li J;Zhang H
通讯作者：
Zhang H