Validating the Patient-Reported Outcomes Measurement Information System Short Form v1.0-Anxiety 8a in a sample of young adult cancer survivors: Comparison with a structured clinical diagnostic interview.
Validating the Patient-Reported Outcomes Measurement Information System Short Form v1.0-Anxiety 8a in a sample of young adult cancer survivors: Comparison with a structured clinical diagnostic interview.
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在年轻的成年癌症幸存者样本中验证患者报告的结果测量信息系统简表 v1.0-焦虑 8a：与结构化临床诊断访谈的比较。
作者：
Recklitis,ChristopherJ;Blackmon,JaimeE;Chevalier,LydiaL;Chang,Grace
背景本研究的目的是验证患者报告结局测量信息系统简表v1.0-焦虑8a（PROMIS‐A‐SF）与结构化诊断访谈进行比较，以确定其准确性和识别年轻成人癌症幸存者（YACSs）焦虑障碍的最合适的截止评分。（50%男性）完成了PROMIS‐A‐SF和精神疾病诊断和统计手册第四版（SCID）的结构化临床访谈。SCID用于确定参与者是否符合焦虑诊断标准。接收操作员的特征进行分析，以确定一致性的PROMIS-A-SF和SCID，以及截止分数的敏感性（≥0.85）和特异性（≥0.75）适当的焦虑筛查measure.ResultsThe PROMIS-A-SF被确定为具有良好的整体歧视相比，SCID（曲线下面积，0.84）。PROMIS-A-SFt-评分临界值≥ 53.2（总预测值，67.9%）最接近于满足研究标准，敏感性为88%，但特异性仅为65%。在一个假设的筛查例子中，这个截止值导致了中等水平的漏诊病例（14%）和一个显着比例的临床转诊，这是不必要的SCID标准（35%）。根据这些标准的幸存者转介的服务，不到三分之一（29%）将有一个SCID焦虑diagnosis.ConclusionsThe PROMIS‐A‐SF表现出中等强度的一致性与焦虑症测量的SCID，但截止分数不符合临床筛选的研究标准。虽然它可能不适合作为一个独立的筛选，PROMIS‐A‐SF可能是有用的评估焦虑在YACS时，它被纳入临床实践或当它与其他措施相结合。
BackgroundThe objective of this study was to validate the Patient‐Reported Outcomes Measurement Information System Short Form v1.0–Anxiety 8a (PROMIS‐A‐SF) against a structured diagnostic interview in order to determine its accuracy and the most appropriate cutoff score for identifying anxiety disorders in young adult cancer survivors (YACSs).MethodsTwo hundred forty‐nine YACSs aged 18 to 40 years (50% male) completed the PROMIS‐A‐SF and the Structured Clinical Interview for theDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition(SCID). The SCID was used to determine whether participants met the criteria for an anxiety diagnosis. Receiving operator characteristic analyses were performed to determine the concordance of the PROMIS‐A‐SF and the SCID as well as cutoff scores with sensitivity (≥0.85) and specificity (≥0.75) appropriate for an anxiety screening measure.ResultsThe PROMIS‐A‐SF was determined to have good overall discrimination in comparison with the SCID (area under the curve, 0.84). A PROMIS‐A‐SFt‐score cutoff ≥ 53.2 (total predictive value, 67.9%) came closest to meeting the study criteria with a sensitivity of 88%, but the specificity was only 65%. In a hypothetical screening example, this cutoff led to moderate levels of missed cases (14%) and a significant proportion of clinical referrals that were unnecessary by SCID criteria (35%). Of the survivors referred for services according to these criteria, less than one‐third (29%) would have a SCID anxiety diagnosis.ConclusionsThe PROMIS‐A‐SF demonstrated moderately strong concordance with anxiety disorders measured by the SCID, but cutoff scores did not meet study criteria for clinical screening. Although it may not be appropriate as a standalone screener, the PROMIS‐A‐SF may be useful for assessing anxiety in YACSs when it is incorporated into clinical practice or when it is combined with other measures.
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