Polypyrrole-Coated Perfluorocarbon Nanoemulsions as a Sono-Photoacoustic Contrast Agent.
Polypyrrole-Coated Perfluorocarbon Nanoemulsions as a Sono-Photoacoustic Contrast Agent.
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DOI：
10.1021/acs.nanolett.7b02845
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发表时间：
2017-10-11
期刊：
影响因子：
10.8
通讯作者：
Pozzo LD
中科院分区：
文献类型：
--
作者：
Li DS;Yoon SJ;Pelivanov I;Frenz M;O'Donnell M;Pozzo LD
提出了一种用于光声与超声联合成像的新型造影剂。它具有直径约250 nm的液体全氟碳(PFC)核心，包覆着30 nm薄的聚吡咯(PPy)掺杂聚合物外壳乳液，代表着覆盖可见光和近红外范围(1050 nm处的峰值光学消光)的宽带吸收体。当暴露在足够高强度的光或声脉冲下时，液滴蒸发形成微泡，从而大大提高了成像的灵敏度和特异度。如果同时用光脉冲和声脉冲照射造影剂，则激活造影剂的阈值可以进一步大幅降低高达两个数量级。选择低沸点的PFC核心液体(即全氟己烷(56°C)、全氟戊烷(29°C)和全氟丁烷(−2°C))有助于激活，并将聚吡咯涂层乳剂造影剂的激活阈值降低到临床安全限度内(在1MJ/cm~2时低至0.2兆帕)。最后，这些纳米乳剂作为造影剂的潜在用途在一系列体模成像研究中得到了证明。
A new contrast agent for combined photoacoustic and ultrasound imaging is presented. It has a liquid perfluorocarbon (PFC) core of about 250 nm diameter coated by a 30 nm thin polypyrrole (PPy) doped polymer shell emulsion which represents a broadband absorber covering the visible and near-infrared ranges (peak optical extinction at 1050 nm). When exposed to a sufficiently high intensity optical or acoustic pulse, the droplets vaporize to form microbubbles providing a strong increase in imaging sensitivity and specificity. The threshold for contrast agent activation can further drastically be reduced by up to two orders of magnitude if simultaneously exposing them with optical and acoustic pulses. The selection of PFC core liquids with low boiling points (i.e. perfluorohexane (56°C), perfluoropentane (29°C) and perfluorobutane (−2°C)) facilitates activation and reduces the activation threshold of PPy coated emulsion contrast agents to levels well within clinical safety limits (as low as 0.2 MPa at 1 mJ/cm2). Finally, the potential use of these nanoemulsions as a contrast agent is demonstrated in a series of phantom imaging studies.
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影响因子：
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作者：
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通讯作者：
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