Lifespan extension of rotifers by treatment with red algal extracts.
Lifespan extension of rotifers by treatment with red algal extracts.
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DOI：
10.1016/j.exger.2013.09.007
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发表时间：
2013-12
影响因子：
3.9
通讯作者：
Kubanek, Julia
中科院分区：
文献类型：
--
作者：
Snare, David J.;Fields, Allison M.;Snell, Terry W.;Kubanek, Julia
衰老是由于大分子损伤的积累抑制了细胞的复制、修复和其他必要的功能。损伤可能是由于环境应激源，如金属毒性，电子转移反应或其他代谢过程中的缺陷引起的氧化应激。为了发现抵消这种损害的医学治疗方法，我们开始使用生命表实验从天然来源中寻找小分子药物，通过他们的公正方法，提供了发现一流分子的机会。我们已经确定了海洋红藻作为天然产品的来源，减缓无脊椎轮虫的老化。轮虫是一个有前途的模式生物延长寿命的研究，因为他们保持一个短暂的，可测量的寿命，同时也有大量的文献与老化。轮虫寿命增加9-14%，暴露于三个共200筛选红藻提取物。生物测定引导分馏导致半纯化的提取物主要由负责轮虫寿命延长的脂质组成。从红刺果中提取的延长生命的混合物含有二十烷酸、十八烷酸和十六烷酸以及几种未鉴定的不饱和脂肪酸。这些小分子混合物的寿命延长效果不是其直接抗氧化能力的结果;可能涉及其他未知的作用机制。了解这些天然产物如何与它们的分子靶点相互作用，可能会导致选择性和有效的治疗方法，以减缓衰老和减少与年龄相关的疾病。
Aging results from an accumulation of damage to macromolecules inhibiting cellular replication, repair, and other necessary functions. Damage may be due to environmental stressors such as metal toxicity, oxidative stress caused by imperfections in electron transfer reactions, or other metabolic processes. In an effort to discover medical treatments that counteract this damage, we initiated a search for small molecule drugs from natural sources using life table experiments which, through their unbiased approach, present the opportunity to discover first-in-class molecules. We have identified marine red algae as a source of natural products that slow aging of the invertebrate rotifer Brachionus manjavacas. Rotifers are a promising model organism for life extension studies as they maintain a short, measurable lifespan while also having an extensive literature related to aging. Rotifer lifespan was increased 9–14% by exposure to three of a total of 200 screened red algal extracts. Bioassay guided fractionation led to semi-purified extracts composed primarily of lipids responsible for rotifer life extension. The life extending mixture from the red alga Acanthophora spicifera contained eicosanoic, octadecanoic, and hexadecanoic acids as well as several unidentified unsaturated fatty acids. The life extending effects of these small molecule mixtures are not a result of their direct antioxidant capacity; other unknown mechanisms of action are likely involved. An understanding of how these natural products interact with their molecular targets could lead to selective and effective treatments for slowing aging and reducing age related diseases.
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影响因子：
46.9
作者：
通讯作者：
--
影响因子：
6.5
作者：
Ichihara, Ken'ichi;Fukubayashi, Yumeto
通讯作者：
Fukubayashi, Yumeto
影响因子：
56.9
作者：
Fabrizio, P;Pozza, F;Longo, VD
通讯作者：
Longo, VD
影响因子：
--
作者：
BOZOVIC, V;ENESCO, HE
通讯作者：
ENESCO, HE
DOI：
10.1093/geronj/16.3.247
发表时间：
1961-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
HARMAN, D
通讯作者：
HARMAN, D