Extracellular vesicles in the treatment and prevention of osteoarthritis: can horses help us translate this therapy to humans?
Extracellular vesicles in the treatment and prevention of osteoarthritis: can horses help us translate this therapy to humans?
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DOI：
10.20517/evcna.2023.11
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发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
Goodrich, Laurie R.
中科院分区：
文献类型：
--
作者：
O'Brien, Thomas J.;Hollinshead, Fiona;Goodrich, Laurie R.
骨关节炎（OA）是一种常见的关节疾病，影响人类和马，导致显着的发病率，财务费用，并失去运动用途。虽然发病机制还不完全清楚，但炎症被认为在疾病的发展和进展中至关重要。间充质基质细胞（MSC）因其抗炎、免疫调节和促再生作用而受到越来越多的科学关注。然而，人们担心它们是否有能力成为商业上可用的治疗剂。细胞外囊泡（EV）现在被认为在用MSC观察到的治疗功效中起关键作用，并且提供了一种潜在的新型无细胞治疗剂，其可以消除MSC的许多问题。有证据表明，EV具有深刻的抗炎，免疫调节和促再生作用，等于或大于它们在治疗OA中来源的MSC。这些研究大多数是在小动物模型中进行的，限制了这些结果对人类的转化。然而，高度转化的动物模型对于进一步了解潜在治疗方法的疗效以及与人类进行密切比较至关重要。出于这个原因，马，它经历了相同的重力影响关节类似于人，是一个高度相关的大型动物物种的测试。马种属具有良好设计和验证的OA模型，此外，可以在天然存在的OA中进一步测试疗法以验证临床前模型测试。因此，马是一个非常合适的模型，以增加我们对EV治疗潜力的了解。
Osteoarthritis (OA) is a common joint disease affecting humans and horses, resulting in significant morbidity, financial expense, and loss of athletic use. While the pathogenesis is incompletely understood, inflammation is considered crucial in the development and progression of the disease. Mesenchymal stromal cells (MSCs) have received increasing scientific attention for their anti-inflammatory, immunomodulatory, and pro-regenerative effects. However, there are concerns about their ability to become a commercially available therapeutic. Extracellular vesicles (EVs) are now recognized to play a crucial role in the therapeutic efficacy observed with MSCs and offer a potentially novel cell-free therapeutic that may negate many of the concerns with MSCs. There is evidence that EVs have profound anti-inflammatory, immunomodulatory, and pro-regenerative effects equal to or greater than the MSCs they are derived from in the treatment of OA. Most of these studies are in small animal models, limiting the translation of these results to humans. However, highly translational animal models are crucial for further understanding the efficacy of potential therapeutics and for close comparisons with humans. For this reason, the horse, which experiences the same gravitational impacts on joints similar to people, is a highly relevant large animal species for testing. The equine species has well-designed and validated OA models, and additionally, therapies can be further tested in naturally occurring OA to validate preclinical model testing. Therefore, the horse is a highly suitable model to increase our knowledge of the therapeutic potential of EVs.
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DOI：
10.3390/ani11113247
发表时间：
2021-11-13
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
Estrada McDermott J;Pezzanite L;Goodrich L;Santangelo K;Chow L;Dow S;Wheat W
通讯作者：
Wheat W
影响因子：
4.3
作者：
Capomaccio, Stefano;Cappelli, Katia;Pascucci, Luisa
通讯作者：
Pascucci, Luisa
影响因子：
1.8
作者：
FOLAND, JW;MCILWRAITH, CW;LAMAR, CH
通讯作者：
LAMAR, CH
影响因子：
4
作者：
Broeckx, Sarah Y.;Seys, Bert;Spaas, Jan H.
通讯作者：
Spaas, Jan H.
影响因子：
2.7
作者：
Baraniak PR;McDevitt TC
通讯作者：
McDevitt TC