Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons.
Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons.
复制标题
使用低沸点完美氟化合物的超声激活纳米颗粒设计。
DOI：
10.1016/j.biomaterials.2012.01.021
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发表时间：
2012-04
期刊：
影响因子：
14
通讯作者：
Dayton, Paul A.
中科院分区：
文献类型：
--
作者：
Sheeran, Paul S.;Luois, Samantha H.;Mullin, Lee B.;Matsunaga, Terry O.;Dayton, Paul A.
关键词：
最近，人们对设计用于医学超声的生物材料产生了兴趣，这种材料可以提供微泡的声学活性，但在体内具有更好的稳定性和更小的尺寸分布，用于血管外探测。一种建议的替代方案是相变造影剂。相变造影剂（PCCAs）由全氟碳化合物（pfc）组成，它们最初是液态的，但随后可以用声能蒸发。pcca的关键参数包括它们对声能的灵敏度，它们的尺寸分布和稳定性，本文提供了pcca的定制设计来平衡这些参数。具体地说，尺寸、热稳定性和超声灵敏度之间的关系是PFC沸点和环境温度的函数。通过在冷凝前混合气态的全氟化合物，可以“调节”乳液的稳定性和灵敏度。新的观察结果表明，具有极低沸点的全氟化合物可以产生稳定的液滴，例如八氟丙烷（b.p. - 36.7°C），可以在比以前观察到的更低的声学参数下汽化。结果表明，低沸点全氟化合物作为一种有用的新型可活化剂化合物的潜力，可以根据所需的应用进行定制。
Recently, an interest has developed in designing in biomaterials for medical ultrasonics that can provide the acoustic activity of microbubbles, but with improved stability in vivo and a smaller size distribution for extravascular interrogation. One proposed alternative is the phase-change contrast agent. Phase-change contrast agents (PCCAs) consist of perfluorocarbons (PFCs) that are initially in liquid form, but can then be vaporized with acoustic energy. Crucial parameters for PCCAs include their sensitivity to acoustic energy, their size distribution, and their stability, and this manuscript provides insight into the custom design of PCCAs for balancing these parameters. Specifically, the relationship between size, thermal stability and sensitivity to ultrasound as a function of PFC boiling point and ambient temperature is illustrated. Emulsion stability and sensitivity can be ‘tuned’ by mixing PFCs in the gaseous state prior to condensation. Novel observations illustrate that stable droplets can be generated from PFCs with extremely low boiling points, such as octafluoropropane (b.p. −36.7°C), which can be vaporized with acoustic parameters lower than previously observed. Results demonstrate the potential for low boiling point PFCs as a useful new class of compounds for activatable agents, which can be tailored to the desired application.
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影响因子：
--
作者：
Mullin, Lee;Gessner, Ryan;Kwan, James;Kaya, Mehmet;Borden, Mark A.;Dayton, Paul A.
通讯作者：
Dayton, Paul A.
影响因子：
3.7
作者：
Fabiilli, Mario L.;Lee, James A.;Kripfgans, Oliver D.;Carson, Paul L.;Fowlkes, J. Brian
通讯作者：
Fowlkes, J. Brian
DOI：
10.1109/tuffc.2002.1009331
发表时间：
2002-06-01
影响因子：
3.6
作者：
Kripfgans, OD;Fowlkes, JB;Carson, PL
通讯作者：
Carson, PL
影响因子：
9.9
作者：
Feshitan, Jameel A.;Chen, Cherry C.;Borden, Mark A.
通讯作者：
Borden, Mark A.
影响因子：
2.9
作者：
Martz, Thomas D.;Sheeran, Paul S.;Bardin, David;Lee, Abraham P.;Dayton, Paul A.
通讯作者：
Dayton, Paul A.