Towards conceptualizing a neural systems-based anatomy of attention-deficit/hyperactivity disorder.

Towards conceptualizing a neural systems-based anatomy of attention-deficit/hyperactivity disorder.
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DOI:
10.1159/000207492
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发表时间:
2009
影响因子:
2.9
通讯作者:
Seidman LJ
Seidman LJ
中科院分区:
医学3区
文献类型:
--
作者:
Makris N;Biederman J;Monuteaux MC;Seidman LJ

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注意缺陷/多动障碍(ADHD)的神经影像、神经心理学、遗传学和神经化学研究的融合数据表明,背侧前额叶皮质(DLPFC)和背侧前扣带回皮质(DACC)功能障碍,这两个皮质形成额纹状体网络的皮质臂,支持执行功能。此外,除了DLPFC和DACC外,结构和功能成像研究还显示,在支持注意力的分布式皮质网络中,关键大脑区域出现了异常。ADHD神经系统生物学的概念化旨在了解ADHD患者的大脑在发育过程中改变了哪些组织原则。使用神经成像表征这些神经系统对于结构内表型的描述至关重要,并可能提供活体分类以及与行为和基因相关的能力。
Convergent data from neuroimaging, neuropsychological, genetic and neurochemical studies in attention-deficit/hyperactivity disorder (ADHD) have implicated dysfunction of the dorsolateral prefrontal cortex (DLPFC) and dorsal anterior cingulate cortex (dACC), which form the cortical arm of the frontostriatal network supporting executive functions. Furthermore, besides the DLPFC and dACC, structural and functional imaging studies have shown abnormalities in key brain regions within distributed cortical networks supporting attention. The conceptualization of neural systems biology in ADHD aims at the understanding of what organizing principles have been altered during development within the brain of a person with ADHD. Characterizing these neural systems using neuroimaging could be critical for the description of structural endophenotypes, and may provide the capability of in vivo categorization and correlation with behavior and genes.
DOI: 10.1212/wnl.47.2.477
发表时间: 1996-08-01
期刊: NEUROLOGY
影响因子: 9.9
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