A lower level of forced expiratory volume in 1 second is a risk factor for all-cause and cardiovascular mortality in a Japanese population: the Takahata study.
A lower level of forced expiratory volume in 1 second is a risk factor for all-cause and cardiovascular mortality in a Japanese population: the Takahata study.
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DOI：
10.1371/journal.pone.0083725
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Shibata Y;Inoue S;Igarashi A;Yamauchi K;Abe S;Aida Y;Nunomiya K;Sato M;Nakano H;Sato K;Nemoto T;Kimura T;Watanabe T;Konta T;Daimon M;Ueno Y;Kato T;Kayama T;Kubota I
在西方国家，慢性阻塞性肺疾病是心血管死亡的已知危险因素。由于日本的心血管死亡率较低，因此日本一般人群中1秒用力呼气量（FEV 1）水平较低与死亡率之间的关系尚不清楚。为了澄清这一点，我们进行了一项以社区为基础的纵向研究。这项研究包括3253名受试者，他们从2004年到2006年在Takahata接受了肺功能测定，并进行了7年的随访。根据死亡证明评估了死亡原因。在338例受试者中，通过肺量测定法观察到气流阻塞。共有127例受试者死亡。心血管死亡是该人群的第二大死因。随访结束时，死亡受试者的肺功能显著低于存活受试者。所有原因导致的死亡、呼吸衰竭、肺癌和心血管疾病的相对危险性随着气流阻塞而显著增加。Kaplan-Meier分析显示，全因和心血管死亡率随着气流阻塞严重程度的加重而显著增加。在调整可能影响预后的因素后，考克斯比例风险模型分析显示，FEV 1水平较低是全因死亡率和心血管死亡率的独立危险因素（每增加10%;风险比[HR]，0.89; 95%置信区间[CI]，0.82-0.98; HR，0.72; 95% CI，0.61-0.86）。总之，气流阻塞是日本普通人群全因死亡和心血管死亡的独立危险因素。肺功能测定可能是一个有用的测试，以评估心血管死亡的风险和检测的风险呼吸死亡的肺癌或呼吸衰竭的健康日本人。
Chronic obstructive pulmonary disease is a known risk factor for cardiovascular death in Western countries. Because Japan has a low cardiovascular death rate, the association between a lower level of forced expiratory volume in 1 s (FEV1) and mortality in Japan’s general population is unknown. To clarify this, we conducted a community-based longitudinal study. This study included 3253 subjects, who received spirometry from 2004 to 2006 in Takahata, with a 7-year follow-up. The causes of death were assessed on the basis of the death certificate. In 338 subjects, airflow obstruction was observed by spirometry. A total of 127 subjects died. Cardiovascular death was the second highest cause of death in this population. The pulmonary functions of the deceased subjects were significantly lower than those of the subjects who were alive at the end of follow-up. The relative risk of death by all causes, respiratory failure, lung cancer, and cardiovascular disease was significantly increased with airflow obstruction. The Kaplan–Meier analysis showed that all-cause and cardiovascular mortality significantly increased with a worsening severity of airflow obstruction. After adjusting for possible factors that could influence prognosis, a Cox proportional hazard model analysis revealed that a lower level of FEV1 was an independent risk factor for all-cause and cardiovascular mortality (per 10% increase; hazard ratio [HR], 0.89; 95% confidence interval [CI], 0.82–0.98; and HR, 0.72; 95% CI, 0.61–0.86, respectively). In conclusion, airflow obstruction is an independent risk factor for all-cause and cardiovascular death in the Japanese general population. Spirometry might be a useful test to evaluate the risk of cardiovascular death and detect the risk of respiratory death by lung cancer or respiratory failure in healthy Japanese individuals.
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影响因子：
5.8
作者：
Agusti A;Calverley PM;Celli B;Coxson HO;Edwards LD;Lomas DA;MacNee W;Miller BE;Rennard S;Silverman EK;Tal-Singer R;Wouters E;Yates JC;Vestbo J;Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
通讯作者：
Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators
影响因子：
3.6
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
通讯作者：
Kubota I
影响因子：
3.6
作者：
Sato M;Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
影响因子：
3.6
作者：
Shibata Y;Watanabe T;Osaka D;Abe S;Inoue S;Tokairin Y;Igarashi A;Yamauchi K;Kimura T;Kishi H;Aida Y;Nunomiya K;Nemoto T;Sato M;Konta T;Kawata S;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
影响因子：
6.9
作者：
Fukuchi, Y;Nishimura, M;Zaher, C
通讯作者：
Zaher, C