Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.
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DOI：
10.1038/msb.2008.40
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发表时间：
2008
影响因子：
9.9
通讯作者：
Nicholson, Jeremy K.
中科院分区：
文献类型：
--
作者：
Martin, Francois-Pierre J.;Wang, Yulan;Sprenger, Norbert;Yap, Ivan K. S.;Rezzi, Serge;Ramadan, Ziad;Pere-Trepat, Emma;Rochat, Florence;Cherbut, Christine;van Bladeren, Peter;Fay, Laurent B.;Kochhar, Sunil;Lindon, John C.;Holmes, Elaine;Nicholson, Jeremy K.
关键词：
肠道微生物-宿主代谢相互作用影响人类健康，可通过添加益生菌和益生菌进行修饰。在这里，我们已经评估了益生菌(副乳杆菌或鼠李糖乳杆菌)和两个半乳糖低聚糖益生菌的组合消费对共生微生物-哺乳动物超系统的影响，方法是在接种了人类婴儿微生物区系模型的无菌小鼠中进行综合代谢谱和多个隔室的建模。当两种益生菌与两种益生菌联合使用时，我们已经显示了两种益生菌对HBM小鼠微生物种群的具体影响。我们观察到长双歧杆菌和短双歧杆菌的数量增加，产气荚膜梭菌减少，当益生素与鼠李糖结合时，这一点更加明显。反过来，这些微生物效应与调节一系列宿主代谢途径有关，这些途径是通过不同细菌菌株发酵碳水化合物所引起的脂类、糖异生以及氨基酸和甲胺代谢的变化观察到的。这些结果为益生元的潜在用途提供了证据，有利于改善肠道微生物平衡以及宿主能量和脂肪平衡。
Gut microbiome–host metabolic interactions affect human health and can be modified by probiotic and prebiotic supplementation. Here, we have assessed the effects of consumption of a combination of probiotics (Lactobacillus paracasei or L. rhamnosus) and two galactosyl-oligosaccharide prebiotics on the symbiotic microbiome–mammalian supersystem using integrative metabolic profiling and modeling of multiple compartments in germ-free mice inoculated with a model of human baby microbiota. We have shown specific impacts of two prebiotics on the microbial populations of HBM mice when co-administered with two probiotics. We observed an increase in the populations of Bifidobacterium longum and B. breve, and a reduction in Clostridium perfringens, which were more marked when combining prebiotics with L. rhamnosus. In turn, these microbial effects were associated with modulation of a range of host metabolic pathways observed via changes in lipid profiles, gluconeogenesis, and amino-acid and methylamine metabolism associated to fermentation of carbohydrates by different bacterial strains. These results provide evidence for the potential use of prebiotics for beneficially modifying the gut microbial balance as well as host energy and lipid homeostasis.
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影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
3.5
作者：
Cuisinier, C;Ward, RJ;de Witte, P
通讯作者：
de Witte, P
影响因子：
7.1
作者：
Delzenne, NM;Kok, N
通讯作者：
Kok, N
影响因子：
3.1
作者：
Gopal, PK;Sullivan, PA;Smart, JB
通讯作者：
Smart, JB
DOI：
10.1073/pnas.0506655103
发表时间：
2006-01-17
影响因子：
11.1
作者：
Bik, EM;Eckburg, PB;Relman, DA
通讯作者：
Relman, DA