Relative Contribution of Proprioceptive and Vestibular Sensory Systems to Locomotion: Opportunities for Discovery in the Age of Molecular Science.
Relative Contribution of Proprioceptive and Vestibular Sensory Systems to Locomotion: Opportunities for Discovery in the Age of Molecular Science.
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DOI：
10.3390/ijms22031467
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发表时间：
2021-02-02
影响因子：
5.6
通讯作者：
Murray AJ
中科院分区：
文献类型：
--
作者：
Akay T;Murray AJ
运动是动物生存所需的基本行为，几个世纪以来一直是神经科学研究的主题。在陆生哺乳动物中，运动过程中有节奏和协调的腿部运动由脊髓中相互连接的神经元（称为中央模式发生器）和来自节段体感系统和脊髓上中心（如前庭系统）的感觉反馈的组合控制。节段性躯体感觉系统和前庭系统如何并行工作以使陆生哺乳动物能够在自然环境中行走仍然相对模糊。在这篇综述中，我们首先简要地描述了什么是已知的两个感觉系统如何控制运动，并使用这些信息来制定一个假设，即部分反馈的作用的重量在较慢的速度是不太重要，但在较高的速度增加，而前庭系统的作用的重量有相反的关系。使用小鼠作为模型系统的分子科学的最新发展所提出的新途径允许直接测试的假设。
Locomotion is a fundamental animal behavior required for survival and has been the subject of neuroscience research for centuries. In terrestrial mammals, the rhythmic and coordinated leg movements during locomotion are controlled by a combination of interconnected neurons in the spinal cord, referred as to the central pattern generator, and sensory feedback from the segmental somatosensory system and supraspinal centers such as the vestibular system. How segmental somatosensory and the vestibular systems work in parallel to enable terrestrial mammals to locomote in a natural environment is still relatively obscure. In this review, we first briefly describe what is known about how the two sensory systems control locomotion and use this information to formulate a hypothesis that the weight of the role of segmental feedback is less important at slower speeds but increases at higher speeds, whereas the weight of the role of vestibular system has the opposite relation. The new avenues presented by the latest developments in molecular sciences using the mouse as the model system allow the direct testing of the hypothesis.
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影响因子：
--
作者：
CAVAGNA, GA;HEGLUND, NC;TAYLOR, CR
通讯作者：
TAYLOR, CR
DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
11.1
作者：
Akay, Turgay;Tourtellotte, Warren G.;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.
影响因子：
2.9
作者：
CARLETON, SC;CARPENTER, MB
通讯作者：
CARPENTER, MB
影响因子：
2.5
作者：
Bolton, D. A. E.;Misiaszek, J. E.
通讯作者：
Misiaszek, J. E.
影响因子：
64.5
作者：
Bikoff JB;Gabitto MI;Rivard AF;Drobac E;Machado TA;Miri A;Brenner-Morton S;Famojure E;Diaz C;Alvarez FJ;Mentis GZ;Jessell TM
通讯作者：
Jessell TM