Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats.
Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats.
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DOI：
10.1111/pme.12057
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Cheng J
中科院分区：
文献类型：
--
作者：
Shen J;Fox LE;Cheng J
神经性疼痛是常见的，并且通常难以治疗，因为它通常对目前可用的止痛药或神经阻滞反应不佳。最近在人类和动物中的研究表明，运动可以诱导短暂的镇痛，并减少正常健康个体的急性疼痛。我们研究了游泳疗法是否可以减轻大鼠的神经病理性疼痛。训练大鼠在温水中游泳两周。训练结束后，通过收缩右侧坐骨神经诱发神经病理性疼痛，并恢复正常游泳。使用Hargreaves测试和von Frey测试监测每个后爪的敏感性，以评价对热和触摸的缩回反应阈值。神经结扎同侧的爪表现出痛样行为，包括热痛觉过敏和机械异常性疼痛。定期游泳治疗显著降低了机械性异常性疼痛和热痛觉过敏。游泳治疗对对侧爪的缩足阈值几乎没有影响。此外，单独的游泳疗法不会改变正常大鼠的热阈值或机械阈值。研究结果表明，定期运动，包括游泳疗法，可能是一种有效的治疗神经损伤引起的神经病理性疼痛。这项研究表明，游泳疗法减少了大鼠的神经性疼痛行为，为临床医生测试运动在神经性疼痛管理中的功效提供了科学依据。它可能被证明是一种安全和成本效益的治疗在各种神经性疼痛状态。
Neuropathic pain is common and often difficult to treat because it generally does not respond well to the currently available pain medications or nerve blocks. Recent studies in both humans and animals have suggested that exercise may induce a transient analgesia and reduce acute pain in normal healthy individuals. We examined whether swim therapy could alleviate neuropathic pain in rats. Rats were trained to swim over a two week period in warm water. After the rats were trained, neuropathic pain was induced by constricting the right sciatic nerve and regular swimming was resumed. The sensitivity of each hind paw was monitored using the Hargreaves test and von Frey test to evaluate the withdrawal response thresholds to heat and touch. The paw ipsilateral to the nerve ligation expressed pain-like behaviors including thermal hyperalgesia and mechanical allodynia. Regular swim therapy sessions significantly reduced the mechanical allodynia and thermal hyperalgesia. Swim therapy had little effect on the withdrawal thresholds for the contralateral paw. In addition, swim therapy alone did not alter the thermal or mechanical thresholds of normal rats. The results suggest that regular exercise, including swim therapy, may be an effective treatment for neuropathic pain caused by nerve injuries. This study, showing that swim therapy reduces neuropathic pain behavior in rats, provides a scientific rationale for clinicians to test the efficacy of exercise in the management of neuropathic pain. It may prove to be a safe and cost-effective therapy in a variety of neuropathic pain states.
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