Cumulative evidence for association of rhinitis and depression.
Cumulative evidence for association of rhinitis and depression.
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DOI：
10.1186/s13223-021-00615-5
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发表时间：
2021-10-24
期刊：
影响因子：
--
通讯作者：
Hu J
中科院分区：
文献类型：
--
作者：
Wang J;Xiao D;Chen H;Hu J
几项初步研究评估了鼻炎与抑郁症发病率之间的关系，结果不一致。我们对评估鼻炎和抑郁之间关系的研究进行了荟萃分析。我们检索了EMBASE、PubMed和Cochrane图书馆数据库，查找2019年4月1日之前发表的英文研究。如果这些研究报告了与抑郁症有关的任何类型的鼻炎，它们就会被纳入研究。两位作者独立提取了这些数据。使用随机效应模型汇总优势比（ORs）。我们进行了分层分析来评估这种关联。在最初确定的3472项研究中，我们根据预先确定的纳入标准纳入了14项研究，共涉及1936±110万受试者。鼻炎(R)、变应性鼻炎（AR）和非变应性鼻炎（NAR）与抑郁的相关性显著，or分别为1.86 （95% CI 1.32 ~ 2.62, p < 0.05）、1.54 （95% CI 1.24 ~ 1.90, p < 0.05）和2.15 （95% CI 1.49 ~ 3.09, p < 0.05）。所有亚组分析结果一致且具有统计学意义。鼻炎与抑郁症的风险增加有关。需要进一步的大样本量的前瞻性研究，通过考虑更多的混杂因素来确认结果并阐明其机制。在线版本包含补充材料，可在10.1186/s13223-021-00615-5获得。
Several primary studies evaluated the association between rhinitis and the incidence of depression and yielded inconsistent results. We conducted a meta-analysis of studies evaluating the association between rhinitis and depression. We searched the EMBASE, PubMed and Cochrane Library databases for studies published in English before April 1, 2019. The studies were included if they reported any type of rhinitis in relation to depression. Two authors independently extracted the data. The odds ratios (ORs) were pooled using a random-effects model. Stratified analyses were conducted to evaluate the association. Among the 3472 initially identified studies, we included 14 studies involving a total of 19.36 ± 1.1 million participants according to predefined inclusion criteria. The associations between rhinitis (R), allergic rhinitis (AR), and nonallergic rhinitis (NAR) and depression were significant with ORs of 1.86 (95% CI 1.32 to 2.62, p < 0.05), 1.54 (95% CI 1.24 to 1.90, p < 0.05), and 2.15 (95% CI 1.49 to 3.09, p < 0.05), respectively. The results were consistent and statistically significant in all subgroup analyses. Rhinitis was associated with an increased risk of depression. Further prospective studies involving large sample sizes are required to confirm the results by considering more confounders and clarify the mechanisms. The online version contains supplementary material available at 10.1186/s13223-021-00615-5.
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