Guidance of myoblast migration on aligned electrospun PLGA nanofibrous meshes

Guidance of myoblast migration on aligned electrospun PLGA nanofibrous meshes
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定向电纺 PLGA 纳米纤维网上成肌细胞迁移的指导

DOI:
10.1016/j.matlet.2011.10.061
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发表时间:
2012-02
期刊:
影响因子:
3
通讯作者:
Gu Zhongwei
Gu Zhongwei
中科院分区:
材料科学3区
文献类型:
--
作者:
Zhang Yong;Lei Ying;Chang Jing;Li Li;He Bin;Gu Zhongwei

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采用静电纺丝技术制备了对齐的聚(L-丙交酯-R-乙交酯)(PLGA)纳米纤维网。通过SEM观察网格的表面图案并测试纤维的直径分布。 C2C12 成肌细胞在电纺纤维上培养。研究了对齐和随机定向纤维 PLGA 网格的细胞增殖和迁移。结果表明,两种表面图案有利于细胞粘附和增殖。排列整齐的纤维可以引导细胞向纤维方向迁移。对齐的表面图案可以更有效地加速细胞外基质的排泄。它提供了一种有前途的控制细胞迁移的模式技术。
Aligned poly(l-lactide-r-glycolide) (PLGA) nanofibrous meshes were prepared by electrospinning technique. The surface patterns of the meshes were observed by SEM and the diameter distribution of the fibers was tested. C2C12 myoblasts were cultured on the electrospun fibers. The cell proliferations and migration of the patterns of aligned and random-oriented fibrous PLGA meshes were investigated. The results showed that the two surface patterns were favorable for cell adhesion and proliferation. The aligned fibers could guide the cells to migrate the fibrous direction. The aligned surface pattern was more efficient to accelerate the excretion of extracellular matrix. It provided a promising pattern technique to control the migration of cells.
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