Neural plasticity in fathers of human infants.

Neural plasticity in fathers of human infants.
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DOI:
10.1080/17470919.2014.933713
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发表时间:
2014
影响因子:
2
通讯作者:
Swain JE
Swain JE
中科院分区:
医学4区
文献类型:
--
作者:
Kim P;Rigo P;Mayes LC;Feldman R;Leckman JF;Swain JE

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父亲在婴儿的社会情感和认知发展中起着重要的作用。以前的研究已经确定了人类母亲对养育行为很重要的大脑区域。然而,人类父亲养育子女的神经基础在很大程度上尚未探索。在当前的纵向研究中,我们使用基于体素的形态测量学(VBM)分析研究了产后前四个月父亲大脑的结构变化。在产后2-4周(时间1)和产后12-16周(时间2)对足月健康婴儿的生物学父亲(n=16)进行扫描。父亲在与父母的动机有关的几个神经区域表现出灰质体积的增加,包括下丘脑、杏仁核、纹状体和外侧前额叶皮质。另一方面,父亲在眶额皮质、后扣带回皮质和小脑皮质的灰质体积减少。这一发现为父亲大脑的神经可塑性提供了证据。我们还讨论了不同的模式之间的关联神经的变化,产后情绪症状,和父亲的养育行为。
Fathering plays an important role in infants’ socioemotional and cognitive development. Previous studies have identified brain regions that are important for parenting behavior in human mothers. However, the neural basis of parenting in human fathers is largely unexplored. In the current longitudinal study, we investigated structural changes in fathers’ brains during the first four months postpartum using voxel-based morphometry (VBM) analysis. Biological fathers (n=16) with full-term, healthy infants were scanned at 2–4 weeks postpartum (Time 1) and at 12–16 weeks postpartum (Time 2). Fathers exhibited increases in gray matter volume in several neural regions involved in parental motivation, including the hypothalamus, amygdala and striatum and lateral prefrontal cortex. On the other hand, fathers exhibited decreases in gray matter volume in the orbitofrontal cortex, posterior cingulate cortex and insula. The findings provide evidence for neural plasticity in fathers’ brains. We also discuss the distinct patterns of associations among neural changes, postpartum mood symptoms, and parenting behaviors among fathers.
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