Serum AMH concentration as a marker evaluating gonadal function in boys operated on for unilateral cryptorchidism between 1st and 4th year of life.
Serum AMH concentration as a marker evaluating gonadal function in boys operated on for unilateral cryptorchidism between 1st and 4th year of life.
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DOI：
10.1007/s12020-011-9551-5
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发表时间：
2012-04
期刊：
影响因子：
3.7
通讯作者：
Zelazowska-Rutkowska, Beata
中科院分区：
文献类型：
--
作者：
Matuszczak, Ewa;Hermanowicz, Adam;Debek, Wojciech;Oksiuta, Marzanna;Dzienis-Koronkiewicz, Ewa;Zelazowska-Rutkowska, Beata
本研究的目的是测量一组患有或不患有隐睾的男孩的血清 AMH（抗苗勒氏管激素）浓度，评估核型、睾丸位置、形态和未降睾丸的主要长度。对 50 名 1-4 岁（中位数 = 2.4 岁）患有单侧隐睾的男孩进行了评估。他们都在 2010 年接受了睾丸固定术。在手术之前，所有受试者都接受了核型分析以排除染色体异常。 2010 年入院计划进行腹股沟疝修补术的 50 名相同年龄范围（中位数 = 2.1 岁）的健康男孩作为对照。收集血液样本，同时获取血液用于手术前常规进行的标准实验室测试。隐睾男孩的 AMH 中位数低于腹股沟疝男孩，两组间差异显着。未降睾丸通常发现于腹股沟浅层贮袋（n = 46），其中两例发现于腹股沟管外环，另外两例发现于腹腔。与正常位置的睾丸相比，未降睾丸的主要长度较小（平均值分别为 1 厘米和平均值 1.5 厘米）。其中九个病例的睾丸膨压不足，呈水滴状，附睾很小，发育不良，与睾丸分离。作者发现，与对照组相比，单侧隐睾男孩（也发现睾丸较小）的 AMH 较低。
The aim of this study was to measure the serum AMH (anti-Mullerian hormone) concentrations in a group of boys with or without cryptorchidism, evaluation of karyotypes, testicular position, morphology, and major length of the undescended testes. Fifty boys who were 1–4 years old (median = 2.4 years) with unilateral cryptorchidism were evaluated. All of them underwent orchidopexy in 2010. Prior to the procedure, all of the subjects had undergone karyotyping to exclude chromosomal abnormalities. Fifty healthy boys within the same age range (median = 2.1 years) admitted for planned inguinal hernia repair in 2010, served as controls. Blood samples were collected, while obtaining blood for standard laboratory tests routinely performed before the surgeries. Medians of AMH in boys with cryptorchidism were lower than in boys with inguinal hernia and differed significantly between two groups. Undescended testes were generally found in superficial inguinal pouch (n = 46), in two cases were noted to be in the external ring of the inguinal canal, and in another two instances, in the abdominal cavity. The major lengths of the undescended testes were smaller in comparison to the testes positioned normally (mean of 1 cm vs. a mean of 1.5 cm, respectively). In nine of the cases, the testes had turgor deficit, a drop shape, with epididymides that were small, dysplastic, and separated from the testis. The authors found that AMH was lower in boys with unilateral cryptorchidism (also found to have smaller testis) when compared with the control group.
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影响因子：
4.1
作者：
Lee, MM;Misra, M;MacLaughlin, DT
通讯作者：
MacLaughlin, DT
影响因子：
3.6
作者：
Berensztein, Esperanza B.;Baquedano, Maria Sonia;Belgorosky, Alicia
通讯作者：
Belgorosky, Alicia
影响因子：
4.1
作者：
Guibourdenche, J;Lucidarme, N;Noël, M
通讯作者：
Noël, M
影响因子：
1.8
作者：
Demircan, M;Akinci, A;Mutus, M
通讯作者：
Mutus, M
影响因子：
5.8
作者：
Aksglaede, L.;Sorensen, K.;Juul, A.
通讯作者：
Juul, A.