Hormonal contraceptive use moderates the association between worry and error-related brain activity.

Hormonal contraceptive use moderates the association between worry and error-related brain activity.
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DOI:
10.1016/j.ijpsycho.2021.11.003
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发表时间:
2022-01
期刊:
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
影响因子:
--
通讯作者:
Moser JS
Moser JS
中科院分区:
其他
文献类型:
--
作者:
Louis CC;Kneip C;Moran TP;Beltz AM;Klump KL;Moser JS

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揭示机制,可以帮助解释的经验和妇女的焦虑的影响是很重要的改善病因模型和治疗,以满足独特的个人的需要。一个扩大的错误相关的负(ERN)-认知控制相关的错误监测的电生理标志-代表的神经过程更强烈相关的女性比男性的一个指标。在这项研究中,我们通过测试激素避孕药(HC)的使用对焦虑之间关系的调节作用,进一步研究了女性中的这种关联,焦虑的跨诊断认知维度和ERN。结果表明,HC调节的担心ERN协会。具体来说,我们发现在使用HC的女性中,担忧和扩大的ERN之间存在显著和巨大的关系,而在自然骑自行车的女性中,这种关系较小且不显著(即,那些不使用HC的人)。这些研究结果表明,HC的使用,错误相关的认知控制和担心之间的相互作用代表了一种新的机制,更好地表征女性的表达和担心的影响。
Uncovering mechanisms that can help explain the experience and impact of anxiety in women is important for improving etiological models and treatments to meet the needs of unique individuals. An enlarged error-related negativity (ERN) – an electrophysiological marker of cognitive control-related error monitoring– represents one indicator of neural processes more strongly related to anxiety in women than men. In this study, we further examined this association in women by testing the moderating effect of hormonal contraceptive (HC) use on the relationship between worry – i.e., a transdiagnostic cognitive dimension of anxiety – and the ERN. Results revealed that HCs moderated the worry-ERN association. Specifically, we found a significant and large relationship between worry and enlarged ERN in women using HCs, which was smaller and nonsignificant in naturally cycling women (i.e., those not using HCs). These findings suggest that the interplay among HC use, error-related cognitive control, and worry represents a novel mechanism for better characterizing the expression and impact of worry in women.
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