Skin Microbiome as Years Go By.
Skin Microbiome as Years Go By.
复制标题
DOI：
10.1007/s40257-020-00549-5
复制
发表时间：
2020-09
影响因子：
7.3
通讯作者：
Luna PC
中科院分区：
文献类型：
--
作者：
Luna PC
皮肤微生物群落，即，微生物群在皮肤屏障功能中起主要作用，因此必须保持动态以适应在人的整个寿命期间在不同身体部位发生的生态位环境的变化。这篇综述概述了在生命的各个阶段皮肤微生物组（微生物和基因组成分）发生的主要变化，从生命的第一周开始，一直到老年人群中的微生物组。有助于确定在各个生命阶段中最影响皮肤微生物组功能，结构和组成的因素的研究被强调，以及影响微生物群群落微妙平衡的改变如何导致正常生理变化并导致皮肤疾病。这篇综述强调了提高我们对所有年龄段人群皮肤微生物组的理解的重要性，以深入了解皮肤病的病理生理学，并允许更好地监测和针对性治疗更脆弱的人群。
The skin microbial communities, i.e., the microbiota, play a major role in skin barrier function so must remain dynamic to adapt to the changes in the niche environment that occur across the different body sites throughout the human lifespan. This review provides an overview of the major alterations occurring in the skin microbiome (microbial and genomic components) during the various stages of life, beginning with its establishment in the first weeks of life through to what is known about the microbiome in older populations. Studies that have helped identify the factors that most influence skin microbiome function, structure, and composition during the various life stages are highlighted, and how alterations affecting the delicate balance of the microbiota communities may contribute to variations in normal physiology and lead to skin disease is discussed. This review underlines the importance of improving our understanding of the skin microbiome in populations of all ages to gain insights into the pathophysiology of skin diseases and to allow better monitoring and targeted treatment of more vulnerable populations.
登录
查看更多内容
影响因子：
6.5
作者：
Capone, Kimberly A.;Dowd, Scot E.;Stamatas, Georgios N.;Nikolovski, Janeta
通讯作者：
Nikolovski, Janeta
影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1073/pnas.1424409112
发表时间：
2015-04-28
影响因子：
11.1
作者：
Bouslimani, Amina;Porto, Carla;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
3.7
作者：
Pammi, Mohan;O'Brien, Jacqueline L.;Petrosino, Joseph F.
通讯作者：
Petrosino, Joseph F.