Seroprevalence and Risk Factors for Q fever (Coxiella burnetii) Exposure in Smallholder Dairy Cattle in Tanzania.
Seroprevalence and Risk Factors for Q fever (Coxiella burnetii) Exposure in Smallholder Dairy Cattle in Tanzania.
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DOI：
10.3390/vetsci9120662
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发表时间：
2022-11-28
影响因子：
2.4
通讯作者：
中科院分区：
文献类型：
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作者：
Q热等导致不孕和流产的人畜共患传染病对中低收入国家日益增长的乳制品部门产生了负面影响，并有可能使疾病蔓延到人口中。2019年7月至2020年10月期间，在坦桑尼亚六个地区的小农奶牛中进行了一项横断面研究，以确定与Q热（贝氏柯克斯体）暴露相关的患病率和风险因素。共采集2049头奶牛血液样本进行了C.伯内特氏菌总体血清阳性率为3.9%。最后的逻辑混合效应回归模型显示，广泛的饲养管理和低降水与Q热血清阳性的因素。结果表明，C.在坦桑尼亚的主要乳制品生产地区，贝氏体在小农奶牛中的传播水平相对较低。控制工作可以集中在降水相对较少的地区或旱季的广泛管理系统，以进一步降低C。贝氏暴露此外，建议采取协调一致的努力，采用“一个健康”的方法进行主动监测，以了解流行病学及其对动物生产和人类健康的影响。Q热是一种人畜共患疾病，由贝氏柯克斯体感染引起。牛的感染可导致流产和不育，然而，关于坦桑尼亚奶牛疾病的流行病学信息很少。在2019年7月至2020年10月期间，在坦桑尼亚的六个高乳制品生产地区进行了血清调查。检测牛血清中的C.使用间接酶联免疫吸附测定法测定贝氏体。混合效应逻辑回归模型确定了与C.贝氏血清阳性。在6个地区的2049头奶牛中，共有79头检测为阳性，总体血清阳性率为3.9%（95% CI 3.06-4.78），其中坦加地区的血清阳性率最高（8.21%，95% CI 6.0-10.89）。与血清阳性相关的风险因素包括：广泛的喂养管理（OR 2.77，95%CI 1.25-3.77）和低于1000 mm的低降水量（OR 2.76，95%CI 1.37-7.21）。在坦桑尼亚的奶牛高产地区，该病的血清阳性率相对较低。由于该疾病具有人畜共患的潜力，今后的努力应采用“一个健康”的方法来了解流行病学，并进行跨学科控制，以减少对动物和人类健康的影响。
Infectious zoonotic diseases that cause infertility and abortion, such as Q fever, negatively impact the growing dairy sector in low- and middle-income countries and represent a risk of spillover of disease into human populations. A cross-sectional study was conducted in smallholder dairy cattle in six regions of Tanzania, between July 2019 and October 2020, to determine the prevalence and the risk factors associated with Q fever (Coxiella burnetii) exposure. A total of 2049 dairy cattle blood samples were collected and tested for antibodies to C. burnetii. The overall seroprevalence was 3.9%. The final logistic mixed effects regression model showed extensive feeding management and low precipitation as factors associated with Q fever seropositivity. The findings indicate that C. burnetii is circulating at relatively low levels among smallholder dairy cattle across the major dairy producing regions in Tanzania. Control efforts could focus on extensive management systems from areas with relatively low precipitation or during the dry season to further reduce the risk of C. burnetii exposure. Moreover, concerted efforts to carry out active surveillance employing a “One Health” approach to understand the epidemiology and its impact in animal production and human health are recommended. Q fever is a zoonotic disease, resulting from infection with Coxiella burnetii. Infection in cattle can cause abortion and infertility, however, there is little epidemiological information regarding the disease in dairy cattle in Tanzania. Between July 2019 and October 2020, a serosurvey was conducted in six high dairy producing regions of Tanzania. Cattle sera were tested for antibodies to C. burnetii using an indirect enzyme-linked immunosorbent assay. A mixed effect logistic regression model identified risk factors associated with C. burnetii seropositivity. A total of 79 out of 2049 dairy cattle tested positive with an overall seroprevalence of 3.9% (95% CI 3.06–4.78) across the six regions with the highest seroprevalence in Tanga region (8.21%, 95% CI 6.0–10.89). Risk factors associated with seropositivity included: extensive feeding management (OR 2.77, 95% CI 1.25–3.77), and low precipitation below 1000 mm (OR 2.76, 95% 1.37–7.21). The disease seroprevalence is relatively low in the high dairy cattle producing regions of Tanzania. Due to the zoonotic potential of the disease, future efforts should employ a “One Health” approach to understand the epidemiology, and for interdisciplinary control to reduce the impacts on animal and human health.
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DOI：
10.4172/2325-9590.1000109
发表时间：
2013-03-22
期刊：
Journal of veterinary science & medical diagnosis
影响因子：
--
作者：
Gumi B;Firdessa R;Yamuah L;Sori T;Tolosa T;Aseffa A;Zinsstag J;Schelling E
通讯作者：
Schelling E
影响因子：
3.7
作者：
Clark NJ;Soares Magalhães RJ
通讯作者：
Soares Magalhães RJ
影响因子：
1.6
作者：
Almogren A;Shakoor Z;Hasanato R;Adam MH
通讯作者：
Adam MH
影响因子：
4.4
作者：
Guatteo, Raphael;Beaudeau, Francois;Seegers, Henri
通讯作者：
Seegers, Henri
影响因子：
1.8
作者：
Derdour, Salima-Yamina;Hafsi, Fella;Ghalmi, Farida
通讯作者：
Ghalmi, Farida