Panretinal Photocoagulation Using Short-Pulse Laser Induces Less Inflammation and Macular Thickening in Patients with Diabetic Retinopathy.
Panretinal Photocoagulation Using Short-Pulse Laser Induces Less Inflammation and Macular Thickening in Patients with Diabetic Retinopathy.
复制标题
DOI：
10.1155/2017/8530261
复制
发表时间：
2017
影响因子：
1.9
通讯作者：
Inatani M
中科院分区：
文献类型：
--
作者：
Takamura Y;Arimura S;Miyake S;Matsumura T;Gozawa M;Iwasaki K;Inatani M
我们比较了使用短脉冲激光（SPL）和传统激光的全视网膜光凝（PRP）对高危非增殖性糖尿病视网膜病变（non-PDR）患者的糖尿病黄斑水肿（DME）进展和前闪强度（AFI）的影响，无论光斑数量如何。42例患者的42只眼接受了常规氩激光（Conv组）或SPL（SPL组）的PRP。SPL组的CRT和AFI水平显著低于Conv组（4、6和10周的CRT; 6、10和18周的AFI）。使用常规激光500点（Conv 500 s）、SPL 500点（SPL 500 s）或1000点（SPL 1000 s）对兔眼进行光凝。采用免疫分析法测定玻璃体液中血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、细胞间粘附分子-1（ICAM-1）和单核细胞趋化蛋白-1（MCP-1）的水平。与常规激光相比，SPL 1000 s和SPL 500 s组的VEGF、IL-6和MCP-1水平显著降低。在高危非PDR患者中，SPL对DME和AFI的进展具有更大的预防作用，并且产生的炎性细胞因子比传统激光更少。
We compared the effect of panretinal photocoagulation (PRP) using short-pulse laser (SPL) and conventional laser, regardless of the number of spots, in terms of their effect on the progression of diabetic macular edema (DME) and anterior flare intensity (AFI) in patients with high-risk nonproliferative diabetic retinopathy (non-PDR). Forty-two eyes of 42 patients were subjected to PRP using the conventional argon laser (Conv group) or SPL (SPL group). CRT and AFI levels in the SPL group were significantly lower than those in the Conv group (CRT at 4, 6, and 10 weeks; AFI at 6, 10, and 18 weeks). Eyes of rabbits were photocoagulated using conventional laser with 500 spots (Conv 500s), SPL with 500 spots (SPL 500s), or 1000 spots (SPL 1000s). Vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemotactic protein-1 (MCP-1) levels in vitreous humor were measured using an immunoassay. Compared to conventional laser, VEGF, IL-6, and MCP-1 levels were significantly lower in the SPL 1000s and SPL 500s groups. In patients with high-risk non-PDR, SPL has a greater preventive effect on the progression of DME and AFI and produces less inflammatory cytokines than conventional lasers.
登录
查看更多内容
影响因子：
4.1
作者：
Sanghvi, C.;McLauchlan, R.;Stanga, P. E.
通讯作者：
Stanga, P. E.
影响因子：
2.1
作者：
Ito, Aiko;Hirano, Yoshio;Ogura, Yuichiro
通讯作者：
Ogura, Yuichiro
影响因子：
4.1
作者：
Muqit, M. M. K.;Marcellino, G. R.;Stanga, P. E.
通讯作者：
Stanga, P. E.
影响因子：
4.1
作者：
Boulton, M;Foreman, D;McLeod, D
通讯作者：
McLeod, D
影响因子：
4.1
作者：
Takahashi, A.;Nagaoka, T.;Yoshida, A.
通讯作者：
Yoshida, A.