Stop-related subthalamic beta activity indexes global motor suppression in Parkinson's disease.
Stop-related subthalamic beta activity indexes global motor suppression in Parkinson's disease.
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与停止相关的丘脑β活动索引了帕金森氏病的全球运动抑制。
DOI：
10.1002/mds.26732
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发表时间：
2016-12
影响因子：
8.6
通讯作者：
Chen, Robert
中科院分区：
文献类型：
--
作者：
Wessel, Jan R.;Ghahremani, Ayda;Udupa, Kaviraja;Saha, Utpal;Kalia, Suneil K.;Hodaie, Mojgan;Lozano, Andres M.;Aron, Adam R.;Chen, Robert
关键词：
快速的动作停止会导致整体运动抑制。使用经颅磁刺激来测量与任务无关的效应器的皮质脊髓兴奋性的研究表明了这一点，例如，在演讲停止时从手上拿下来我们假设这种全局抑制与基底神经节的丘脑底核有关。在帕金森氏症患者中进行的几项局部场电位研究表明，在成功停止期间，高频带功率增加。在这里，我们的目的是测试是否这种脑电波的活动指标的整体运动抑制测量经颅磁刺激。我们研究了9名植入STN-DBS电极的药物治疗PD患者（年龄：47 - 67岁，平均年龄：55.8岁; 3名女性）。参与者执行声音停止信号任务（即，他们不得不偶尔停止声音反应），同时我们记录了右前臂的局部场电位，并向初级运动皮层传递经颅磁刺激，以测量与任务无关的手部肌肉（第一背侧骨间肌）的皮质脊髓兴奋性。重复先前的结果，在成功停药期间，脑电波功率增加（p < .005），皮质脊髓兴奋性降低（p = .024）（整体运动抑制）。正如假设的那样，这种全局运动抑制在具有较高的肌电功率的成功停止试验中更大（中位数分裂：p = 0.043），这在单次试验肌电功率和皮质脊髓兴奋性之间的负相关性中进一步明显（平均r =-0.176，p = 0.011）。这些发现通过同时记录大脑皮层和皮质脊髓的兴奋性，将停跳相关的全局运动抑制与脑电波活动联系起来。研究结果支持了基底神经节模型，该模型提出了海马具有广泛的运动抑制作用。
Rapid action-stopping leads to global motor suppression. This is shown by studies using Transcranial Magnetic Stimulation to measure corticospinal excitability of task-unrelated effectors, e.g., from the hand during speech-stopping. We hypothesize this global suppression relates to the subthalamic nucleus of the basal ganglia. Several STN local field potential studies in Parkinson’s patients have shown increased ß-band power during successful stopping. Here, we aimed to test whether this STN ß-band activity indexes global motor suppression measured by transcranial magnetic stimulation. We studied nine medicated PD patients (age: 47 – 67y, mean: 55.8; 3 female) who were implanted with STN-DBS electrodes. Participants performed a vocal stop-signal task (i.e., they had to occasionally stop a vocal response) while we simultaneously recorded local field potentials from right STN and delivered transcranial magnetic stimulation to primary motor cortex to measure corticospinal excitability from a task-unrelated hand muscle (first dorsal interosseous). Replicating prior results, STN ß-band power was increased (p < .005) and corticospinal excitability was reduced (p = .024) (global motor suppression) during successful stopping. As hypothesized, such global motor suppression was greater for successful stop-trials with higher STN ß-power (median-split: p = .043), which was further evident in a negative correlation between single-trial STN ß-power and corticospinal excitability (mean r = -.176, p = .011). These findings link stopping-related global motor suppression to STN ß-band activity through simultaneous recordings of STN and corticospinal excitability. The results support models of basal ganglia that propose the STN has broad motor suppressive effects.
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影响因子：
16.2
作者：
Leventhal DK;Gage GJ;Schmidt R;Pettibone JR;Case AC;Berke JD
通讯作者：
Berke JD
影响因子：
6.8
作者：
Bastin J;Polosan M;Benis D;Goetz L;Bhattacharjee M;Piallat B;Krainik A;Bougerol T;Chabardès S;David O
通讯作者：
David O
影响因子：
5.3
作者：
Isoda, Masaki;Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide
影响因子：
4.8
作者：
Keuken MC;Van Maanen L;Bogacz R;Schäfer A;Neumann J;Turner R;Forstmann BU
通讯作者：
Forstmann BU
影响因子：
3.2
作者：
Cavanagh, James F.;Sanguinetti, Joseph L.;Frank, Michael J.
通讯作者：
Frank, Michael J.