Body mass index and risk of ovarian cancer.
Body mass index and risk of ovarian cancer.
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DOI：
10.1002/cncr.24086
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发表时间：
2009-02-15
期刊：
影响因子：
6.2
通讯作者：
Lacey, James V., Jr.
中科院分区：
文献类型：
--
作者：
Leitzmann, Michael F.;Koebnick, Corinna;Danforth, Kim N.;Brinton, Louise A.;Moore, Steven C.;Hollenbeck, Albert R.;Schatzkin, Arthur;Lacey, James V., Jr.
令人信服的流行病学证据将超重与子宫内膜癌和绝经后乳腺癌的风险增加联系起来，但体重指数（BMI）与卵巢癌风险的关系仍不确定。女性癌症病因学中激素机制的潜在相似性突出了根据绝经期激素治疗（MHT）使用调查相关性的重要性。然而，关于BMI与卵巢癌的关系是否因MHT的使用而不同的数据非常稀少。我们前瞻性地调查了94,525名美国妇女的BMI与卵巢癌之间的关系，随访时间为1996-1997年至2003年12月31日。在7年的随访中，我们记录了303例上皮性卵巢癌病例。与正常体重妇女（BMI 18.5-24.9 kg/m2）相比，肥胖妇女（BMI ≥30 kg/m2）患卵巢癌的多变量相对危险度（MVRR）为1.25（95%CI =0.93-1.68）。在从未使用过MHT的女性中，肥胖与正常体重女性的MVRR为1.80（95%-CI=1.16-2.80）。相比之下，在曾经使用过MHT的女性中，BMI与卵巢癌之间没有明显的关系（MVRR=0.96; 95%CI =0.64-1.43; P-交互作用=0.02）。探索性分析还表明，在没有卵巢癌家族史的女性中，BMI与卵巢癌呈正相关（肥胖与正常体重女性的MVRR =1.36; 95%-CI=0.99-1.85），但在有卵巢癌家族史的女性中，BMI与MVRR无明显关系。（MVRR=0.73; 95%-CI=0.34-1.60; P-相互作用=0.02）。我们怀疑肥胖通过激素机制与卵巢癌风险增加有关。
Convincing epidemiologic evidence links excess body mass to increased risks of endometrial and postmenopausal breast cancers but the relation of body mass index (BMI) to ovarian cancer risk remains inconclusive. Potential similarities regarding a hormonal mechanism in the etiology of female cancers highlight the importance of investigating associations according to menopausal hormone therapy (MHT) use. However, data addressing whether the relation of BMI to ovarian cancer differs by MHT use are very sparse. We prospectively investigated the association between BMI and ovarian cancer among 94,525 U.S. women, followed from 1996–1997 to December 31, 2003. During 7 years of follow-up, we documented 303 epithelial ovarian cancer cases. As compared with normal weight women (BMI 18.5–24.9 kg/m2), the multivariate relative risk (MVRR) of ovarian cancer for obese women (BMI ≥30 kg/m2) in the cohort as a whole was 1.25 (95%-CI=0.93–1.68). Among women who never used MHT, the MVRR for obese versus normal weight women was 1.80 (95%-CI=1.16–2.80). In contrast, no relation between BMI and ovarian cancer was apparent among women who ever used MHT (MVRR=0.96; 95%-CI=0.64–1.43; P-interaction=0.02). Exploratory analyses also suggested a positive association between BMI and ovarian cancer among women without a family history of ovarian cancer (MVRR comparing obese versus normal weight women=1.36; 95%-CI=0.99–1.85), but no relation with BMI was apparent among women with a positive family history of ovarian cancer (MVRR=0.73; 95%-CI=0.34–1.60; P-interaction=0.02). We suspect that obesity is associated with enhanced ovarian cancer risk through a hormonal mechanism.
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影响因子：
4.7
作者：
Kurian, AW;Balise, RR;Whittemore, AS
通讯作者：
Whittemore, AS
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