Anodal transcranial direct current stimulation of the prefrontal cortex enhances complex verbal associative thought.
Anodal transcranial direct current stimulation of the prefrontal cortex enhances complex verbal associative thought.
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DOI：
10.1162/jocn.2008.21143
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发表时间：
2009-10
影响因子：
3.2
通讯作者：
Schlaug G
中科院分区：
文献类型：
--
作者：
Cerruti C;Schlaug G
远距离联想测试(RAT)是一项复杂的语言测试，与创造性思维和一般智力都有关联。老鼠问题不仅需要横向联想和许多单词的内部产生，而且需要集中精力寻找一个单一的答案。因此，解决这类复杂问题可能既需要大量的语言处理能力，也需要强大的执行功能能力。以往的研究已经证明，非侵入性经颅直流电刺激(TDC)可以提高言语任务成绩。Tdcs根据电流的极性调节神经组织的兴奋性。如果被检查的任务利用调制区域，则该调制的后效可能会对任务绩效产生影响。言语认知的研究主要集中在左侧背外侧前额叶皮质(10-20脑电信号系统的F3)作为感兴趣区。我们计划评估在F3调节兴奋性是否会影响复杂的语言能力。在实验1中(用对侧眶上区域的参比电极对F3进行阳极、阴极或假刺激)，我们发现刺激条件对大鼠的表现有显著的总体影响。后测试显示，与假刺激(p=.025)和阴极刺激(p=.038)相比，阳极刺激(1 MA)后的表现有所提高。在实验2(分别刺激F3或其同系物F4)中，我们复制了第一个研究的阳极效应，但也表明刺激F4对大鼠的表现没有影响。这些数据提供了证据，证明刺激左侧背外侧前额叶皮质可以改善复杂的语言问题解决任务的表现，据信这项任务需要显着的执行功能能力。
The remote associates test (RAT) is a complex verbal task with associations to both creative thought and general intelligence. RAT problems require not only lateral associations and the internal production of many words but a convergent focus on a single answer. Complex problem-solving of this sort may thus require both substantial verbal processing and strong executive function capacities. Previous studies have provided evidence that verbal task performance can be enhanced by noninvasive transcranial direct current stimulation (tDCS). tDCS modulates excitability of neural tissue depending on the polarity of the current. The after-effects of this modulation may have effects on task performance if the task examined draws on the modulated region. Studies of verbal cognition have focused largely on the left dorsolateral prefrontal cortex (F3 of the 10–20 EEG system) as a region of interest. We planned to assess whether modulating excitability at F3 could affect complex verbal abilities. In Experiment 1 (anodal, cathodal, or sham stimulation over F3 with the reference electrode over the contralateral supraorbital region), we found a significant overall effect of stimulation condition on RAT performance. Post hoc tests showed an increase in performance after anodal stimulation (1 mA) compared to sham (p = .025) and to cathodal stimulation (p = .038). In Experiment 2 (either anodal stimulation at F3 or separately at its homologue F4), we replicated the anodal effect of the first study, but also showed that anodal stimulation of F4 had no effect on RAT performance. These data provide evidence that anodal stimulation of the left dorsolateral prefrontal cortex can improve performance on a complex verbal problem-solving task believed to require significant executive function capacity.
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影响因子：
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