Effect of Electroacupuncture at ST36 on Gastric-Related Neurons in Spinal Dorsal Horn and Nucleus Tractus Solitarius

Effect of Electroacupuncture at ST36 on Gastric-Related Neurons in Spinal Dorsal Horn and Nucleus Tractus Solitarius
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电针ST36对脊髓背角及孤束核胃相关神经元的影响

DOI:
10.1155/2013/912898
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发表时间:
2013-09
影响因子:
--
通讯作者:
景向红
景向红
中科院分区:
医学4区
文献类型:
--
作者:
陈淑莉;Gerhard Litscher;Ingrid Gaischek;景向红

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本研究旨在观察电针ST36穴对大鼠脊背角(SDH)和孤束核(NTS)胃相关神经元放电率的影响。SDH和NTS对46只雄性sd大鼠胃胀的影响不同。在SDH的10个兴奋性神经元中,大部分神经元被同侧EA抑制,NTS的10个胃相关兴奋性神经元的放电率显著降低(P < 0.05);同侧电刺激可进一步刺激6个神经元的放电率,且放电率显著升高(P < 0.05);与对侧EA相比,同侧EA对SDH胃相关神经元的抑制率显著升高(P < 0.05)。NTS胃相关神经元同侧EA与对侧EA无显著性差异。ST36时EA改变SDH和NTS胃相关神经元的放电速率。然而,这些神经元的反应模式存在一些差异。这些差异的存在可能是EA效应多样性和复杂性的生理基础之一。
The aim of this study was to observe the effect of electroacupuncture (EA) at the ST36 acupoint on the firing rate of gastric-related neurons in the spinal dorsal horn (SDH) and nucleus tractus solitarius (NTS). There were different effects of gastric distention in SDH and NTS in 46 male Sprague-Dawley rats. In 10 excitatory neurons in SDH, most of the neurons were inhibited by homolateral EA. The firing rates decreased significantly (P < 0.05) in 10 excitatory gastric-related neurons in NTS; the firing rates of 6 neurons were further excited by homolateral EA, with a significant increase of the firing rates (P < 0.05); all inhibitory gastric-related neurons in NTS were excited by EA. The inhibition rate of homolateral EA was significantly increased in comparison with contralateral EA in gastric-related neurons of SDH (P < 0.05). There was no significant difference between homolateral and contralateral EA in gastric-related neurons of NTS. EA at ST36 changes the firing rate of gastric-related neurons in SDH and NTS. However, there are some differences in responsive mode in these neurons. The existence of these differences could be one of the physiological foundations of diversity and complexity in EA effects.
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