Neural representation of swallowing is retained with age. A functional neuroimaging study validated by classical and Bayesian inference
Neural representation of swallowing is retained with age. A functional neuroimaging study validated by classical and Bayesian inference
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吞咽的神经表征随着年龄的增长而保留 通过经典和贝叶斯推理验证的功能性神经影像研究
DOI：
10.1016/j.bbr.2015.03.009
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发表时间：
2015
影响因子：
2.7
通讯作者：
Lotze M.
中科院分区：
文献类型：
--
作者：
Windel A. S;Mihai P. G;Lotze M.
我们使用高空间分辨率功能磁共振成像 (fMRI) 研究了两个年龄组中总共 51 名健康参与者（老年人：平均年龄 64 岁；年轻人：平均年龄 24 岁）吞咽的神经表征。两项统计比较（经典推理和贝叶斯推理）显示，除了使用贝叶斯推理得出的布罗德曼 10 区额极 1 的老年人的皮质激活程度更高之外，受试者组之间没有显着差异。与年轻参与者相比，老年人在吞咽过程中表现出更长的反应时间和更高的皮肤电导反应（SCR）。我们发现仅在老年人中处理感觉运动表现、唤醒和情绪感知的区域中 SCR 和 fMRI 激活呈正相关。结果表明，高度自动化的吞咽网络随着年龄的增长仍保留其功能。然而，吞咽过程中 SCR 较高的老年人似乎也参与了涉及注意力控制和情绪调节的区域，这可能表明在任务执行过程中注意力和情绪需求增加。
We investigated the neural representation of swallowing in two age groups for a total of 51 healthy participants (seniors: average age 64 years; young adults: average age 24 years) using high spatial resolution functional magnetic resonance imaging (fMRI). Two statistical comparisons (classical and Bayesian inference) revealed no significant differences between subject groups, apart from higher cortical activation for the seniors in the frontal pole 1 of Brodmann's Area 10 using Bayesian inference. Seniors vs. young participants showed longer reaction times and higher skin conductance response (SCR) during swallowing. We found a positive association of SCR and fMRI-activation only among seniors in areas processing sensorimotor performance, arousal and emotional perception. The results indicate that the highly automated swallowing network retains its functionality with age. However, seniors with higher SCR during swallowing appear to also engage areas involved in attention control and emotional regulation, possibly suggesting increased attention and emotional demands during task performance.
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影响因子：
4.8
作者：
Mihai, Paul Glad;Otto, Mareile;Lotze, Martin
通讯作者：
Lotze, Martin
影响因子：
2
作者：
Mosier, K;Bereznaya, I
通讯作者：
Bereznaya, I
影响因子：
5.7
作者：
Hutchinson, S;Kobayashi, M;Schlaug, G
通讯作者：
Schlaug, G
影响因子：
2.7
作者：
Loibl, M.;Beutling, W.;Lotze, M.
通讯作者：
Lotze, M.
皮质吞咽处理的年龄相关变化
影响因子：
4.2
作者：
I. Teismann;O. Steinstraeter;W. Schwindt;E. Ringelstein;C. Pantev;R. Dziewas
通讯作者：
R. Dziewas