Challenges and Perspectives of Mapping Locus Coeruleus Activity in the Rodent with High-Resolution fMRI.
Challenges and Perspectives of Mapping Locus Coeruleus Activity in the Rodent with High-Resolution fMRI.
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DOI：
10.3390/brainsci12081085
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发表时间：
2022-08-16
期刊：
影响因子：
3.3
通讯作者：
Yu, Xin
中科院分区：
文献类型：
--
作者：
Zhou, Xiaoqing Alice;Jiang, Yuanyuan;Napadow, Vitaly;Yu, Xin
蓝斑核（LC）是研究脑行为关联时最常被研究的脑干核之一。LC在自下而上上升和自上而下下降的投射中起着主要的脑干中继作用。具体来说，去甲肾上腺素能（NA） LC神经元不仅连接到高阶皮层下核和皮层来调节唤醒和注意，而且直接投射到其他脑干核和脊髓来控制自主神经功能。尽管利用电生理记录和细胞/分子成像对LC功能进行了广泛的研究，用于认知研究和LC对不同病理状态的贡献，但神经影像学在LC功能研究中的作用受到限制。例如，由于该核的体积较小，在动物模型中使用功能性MRI （fMRI）识别lc特异性激活仍然具有挑战性。在这里，我们通过强调技术挑战来讨论fMRI应用于小鼠大脑LC活动映射的复杂性。此外，我们引入了一种单血管功能磁共振成像成像方法，以阐明高分辨率功能磁共振成像信号与小鼠脑干LC激活耦合的血管特异性。
The locus coeruleus (LC) is one of the most commonly studied brainstem nuclei when investigating brain–behavior associations. The LC serves as a major brainstem relay for both ascending bottom-up and descending top-down projections. Specifically, noradrenergic (NA) LC neurons not only connect globally to higher-order subcortical nuclei and cortex to mediate arousal and attention but also directly project to other brainstem nuclei and to the spinal cord to control autonomic function. Despite the extensive investigation of LC function using electrophysiological recordings and cellular/molecular imaging for both cognitive research and the contribution of LC to different pathological states, the role of neuroimaging to investigate LC function has been restricted. For instance, it remains challenging to identify LC-specific activation with functional MRI (fMRI) in animal models, due to the small size of this nucleus. Here, we discuss the complexity of fMRI applications toward LC activity mapping in mouse brains by highlighting the technological challenges. Further, we introduce a single-vessel fMRI mapping approach to elucidate the vascular specificity of high-resolution fMRI signals coupled to LC activation in the mouse brainstem.
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