Major reduction of rotavirus, but not norovirus, gastroenteritis in children seen in hospital after the introduction of RotaTeq vaccine into the National Immunization Programme in Finland.
Major reduction of rotavirus, but not norovirus, gastroenteritis in children seen in hospital after the introduction of RotaTeq vaccine into the National Immunization Programme in Finland.
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DOI：
10.1007/s00431-013-1945-3
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发表时间：
2013-06
影响因子：
3.6
通讯作者：
Vesikari T
中科院分区：
文献类型：
--
作者：
Hemming M;Räsänen S;Huhti L;Paloniemi M;Salminen M;Vesikari T
普遍轮状病毒（RV）疫苗接种有望通过消除大部分严重的RVGE来减少儿童急性胃肠炎（GE）的住院率，但它对诺如病毒（NV）没有任何影响，诺如病毒是儿童GE的第二常见病原体。 2009 年将 RV 疫苗引入芬兰国家免疫计划 (NIP) 后，我们对坦佩雷大学医院门诊或住院儿童的 GE 进行了一项为期 2 年的前瞻性调查，并将结果与 NIP 之前 2006-2008 年进行的类似 2 年调查进行了比较。与 NIP 之前的两年相比，2009 年至 2011 年，RVGE 住院人数减少了 76%，门诊量减少了 81%。 NVGE 呈轻微下降趋势，占医院所有 GE 病例的 34%（根据 RVGE 下降至 26%（低于 52%））。在医院病房收治的病例中，RV 占 28%，NV 占 37%。RV 疫苗接种的影响体现为所有因任何原因 GE 住院的人数减少了 57%，所有门诊就诊人数减少了 62%。结论：NIP 中的 RV 疫苗接种导致 RVGE 导致的住院和就诊次数大幅减少，但对 NVGE 没有影响。 NIP 实施两年后，NV 已成为住院儿童急性 GE 的主要原因。
Universal rotavirus (RV) vaccination is expected to reduce hospitalizations for acute gastroenteritis (GE) of children by eliminating most of severe RVGE, but it does not have any effect on norovirus (NV), the second most common causative agent of GE in children. After the introduction of the RV vaccine into the National Immunization Programme (NIP) of Finland in 2009, we conducted a prospective 2-year survey of GE in children seen in Tampere University Hospital either as outpatients or inpatients and compared the results with a similar 2-year survey conducted prior to NIP in the years 2006–2008. Compared with the pre-NIP 2-year period, in 2009–2011, hospitalizations for RVGE were reduced by 76 % and outpatient clinic visits were reduced by 81 %. NVGE showed a slight decreasing trend and accounted for 34 % of all cases of GE seen in hospital in pursuance of RVGE having decreased to 26 % (down from 52 %). In cases admitted to the hospital ward, RV accounted for 28 % and NV accounted for 37 %.The impact of RV vaccination was reflected as a 57 % decrease in all hospital admissions and 62 % decrease in all outpatient clinic visits for GE of any cause. Conclusion: RV vaccination in NIP has led to a major reduction of hospital admissions and clinic visits due to RVGE, but has had no effect on NVGE. After 2 years of NIP, NV has become the leading cause of acute GE in children seen in hospital.
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影响因子：
3.6
作者：
Braeckman, Tessa;Van Herck, Koen;Van Damme, Pierre
通讯作者：
Van Damme, Pierre
影响因子：
158.5
作者：
PARRINO, TA;SCHREIBER, DS;BLACKLOW, NR
通讯作者：
BLACKLOW, NR
影响因子：
11.8
作者：
Patel, Manish M.;Widdowson, Marc-Alain;Glass, Roger I.;Akazawa, Kenichiro;Vinje, Jan;Parashar, Umesh D.
通讯作者：
Parashar, Umesh D.
影响因子：
8
作者：
Payne, Daniel C.;Edwards, Kathryn M.;Gentsch, Jon R.
通讯作者：
Gentsch, Jon R.
影响因子：
4.2
作者：
Iturriza-Gomara, M.;Dallman, T.;Gray, J.
通讯作者：
Gray, J.