A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma.
A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma.
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DOI：
10.1289/ehp.1002106
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发表时间：
2011-02
影响因子：
10.4
通讯作者：
Colt JS
中科院分区：
文献类型：
--
作者：
Purdue MP;Bakke B;Stewart P;De Roos AJ;Schenk M;Lynch CF;Bernstein L;Morton LM;Cerhan JR;Severson RK;Cozen W;Davis S;Rothman N;Hartge P;Colt JS
以前的流行病学研究结果表明，暴露于三氯乙烯（TCE），主要用于金属部件的蒸汽消毒的氯化溶剂，和非霍奇金淋巴瘤（NHL）之间的关联。我们在一项基于人群的病例对照研究中使用详细的暴露评估方法调查了职业性TCE暴露与NHL之间的关联。病例组（n = 1，189;参与率76%）和对照组（n = 982;参与率52%）提供了有关其职业史的信息，并使用特定工作访谈模块，就选定职业提供了有关可能在工作场所接触三氯乙烯的信息。一位工业卫生学家根据这一信息和对三氯乙烯工业卫生文献的审查，评估了潜在的三氯乙烯接触。我们计算了与NHL相关的比值比（OR）和95%置信区间（CI），以及估计TCE暴露的不同指标，使用暴露对照组的三分位数进行分类，未暴露受试者作为参考组。我们观察到TCE的估计平均每周暴露量（23例暴露病例; OR = 2.5; 95%CI，1.1-6.1）和累积暴露量（24例暴露病例; OR = 2.3; 95%CI，1.0-5.0）的最高三分位数与NHL相关。这些指标的趋势检验超过或接近统计学显著性（趋势的p值分别为0.02和0.08）;然而，我们没有观察到暴露水平之间的剂量-反应关系。总体而言，暴露时间和强度均与NHL无关，尽管我们观察到与暴露时间最低三分位数相关（OR = 2.1; 95%CI，1.0-4.7）。我们的研究结果为高水平接触TCE和NHL风险增加之间的关联提供了额外的支持。但是，我们不能排除来自用于蒸汽灭菌的其他氯化溶剂的混淆可能性，并注意到我们的暴露评估方法尚未经过验证。
Previous epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL). We investigated the association between occupational TCE exposure and NHL within a population-based case–control study using detailed exposure assessment methods. Cases (n = 1,189; 76% participation rate) and controls (n = 982; 52% participation rate) provided information on their occupational histories and, for selected occupations, on possible workplace exposure to TCE using job-specific interview modules. An industrial hygienist assessed potential TCE exposure based on this information and a review of the TCE industrial hygiene literature. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating NHL and different metrics of estimated TCE exposure, categorized using tertiles among exposed controls, with unexposed subjects as the reference group. We observed associations with NHL for the highest tertiles of estimated average weekly exposure (23 exposed cases; OR = 2.5; 95% CI, 1.1–6.1) and cumulative exposure (24 exposed cases; OR = 2.3; 95% CI, 1.0–5.0) to TCE. Tests for trend with these metrics surpassed or approached statistical significance (p-value for trend = 0.02 and 0.08, respectively); however, we did not observe dose–response relationships across the exposure levels. Overall, neither duration nor intensity of exposure was associated with NHL, although we observed an association with the lowest tertile of exposure duration (OR = 2.1; 95% CI, 1.0–4.7). Our findings offer additional support for an association between high levels of exposure to TCE and increased risk of NHL. However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated.
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影响因子：
10.4
作者：
Cooper GS;Makris SL;Nietert PJ;Jinot J
通讯作者：
Jinot J
影响因子：
4.9
作者：
Blair, A;Hartge, P;Lubin, J
通讯作者：
Lubin, J
DOI：
10.1097/00043764-199507000-00008
发表时间：
1995-07-01
影响因子：
3.2
作者：
ANTTILA, A;PUKKALA, E;HEMMINKI, K
通讯作者：
HEMMINKI, K
影响因子：
5
作者：
Raaschou-Nielsen, O;Hansen, J;Olsen, JH
通讯作者：
Olsen, JH
影响因子：
20.3
作者：
Morton, Lindsay M.;Turner, Jennifer J.;Weisenburger, Dennis D.
通讯作者：
Weisenburger, Dennis D.