Intake frequency of fish and serum levels of long-chain n-3 fatty acids: a cross-sectional study within the Japan Collaborative Cohort Study.
Intake frequency of fish and serum levels of long-chain n-3 fatty acids: a cross-sectional study within the Japan Collaborative Cohort Study.
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DOI：
10.2188/jea.15.211
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发表时间：
2005-11
影响因子：
4.7
通讯作者：
JACC Study Group
中科院分区：
文献类型：
--
作者：
Wakai K;Ito Y;Kojima M;Tokudome S;Ozasa K;Inaba Y;Yagyu K;Tamakoshi A;JACC Study Group
背景：多项研究采用自我报告的鱼类摄入频率作为长链 n-3 脂肪酸摄入量的替代指标，表明长链 n-3 脂肪酸具有抗癌作用。然而，报告的鱼类消费量是否反映了脂肪酸的摄入量仍需阐明。方法：我们在日本协作队列研究的病例对照研究中，研究了 1,257 名年龄 40-79 岁的对照受试者（631 名男性和 626 名女性）的鱼类摄入频率与血清长链 n-3 脂肪酸（总脂肪酸的重量百分比）之间的关联。抽血时所有受试者均未禁食。通过气相色谱法测定血清脂肪酸。结果：在男性中，鲜鱼和干鱼或咸鱼的摄入频率与二十碳五烯酸（EPA）、二十二碳五烯酸（n-3）（DPA）和二十二碳六烯酸（DHA）的血清水平显着但微弱相关；年龄调整后的 Spearman 相关系数范围为 0.11 至 0.18。在女性中，新鲜鱼的摄入量与血清 EPA 存在一定的相关性（斯皮尔曼相关系数 = 0.12），干鱼或咸鱼的摄入量与血清 DPA 存在一定的相关性（0.11）。研究发现，无论男女，随着新鲜鱼或干鱼/咸鱼摄入频率的增加，血清 EPA、DPA 和 DHA 的几何平均值呈上升趋势。根据年龄和参与机构调整后，最高入学类别的几何平均值比最低入学类别高 7% 至 40%。结论：自我报告鱼类摄入频率较高的人群作为一个群体，其长链 n-3 脂肪酸的生物利用度可能高于频率较低的人群。
BACKGROUND: Several investigations have adopted self-reported intake frequency of fish as a surrogate for intake of long-chain n-3 fatty acids, for which protective effects against cancer have been suggested. Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated. METHODS: We examined the association between intake frequency of fish and serum long-chain n-3 fatty acids (weight percentage of total fatty acids) among 1,257 control subjects (631 men and 626 women), aged 40-79 years, in case-control studies nested in the Japan Collaborative Cohort Study. All the subjects were not fasting when blood was drawn. Serum fatty acids were determined by gas chromatography. RESULTS: In men, intake frequency of fresh fish and dried or salted fish was significantly but weakly correlated with serum levels of eicosapentaenoic (EPA), docosapentaenoic (n-3) (DPA), and docosahexaenoic (DHA) acids; the age-adjusted Spearman correlation coefficients ranged from 0.11 to 0.18. In women, fresh fish consumption was somewhat associated with serum EPA (Spearman correlation coefficient = 0.12) as was dried or salted fish consumption with serum DPA (0.11). A rising trend in geometric means of serum EPA, DPA, and DHA was found with an increasing intake frequency of fresh or dried/salted fish in both sexes. The geometric means adjusted for age and participating institution in the highest intake category were higher than those in the lowest by 7% to 40%. CONCLUSIONS: A population with high self-reported frequency of fish intake, as a group, may have higher bioavailability of long-chain n-3 fatty acids than one with low frequency.
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影响因子：
5
作者：
Kojima, M;Wakai, K;Tamakoshi, A
通讯作者：
Tamakoshi, A
影响因子：
6.4
作者：
Hirose, K;Takezaki, T;Tajima, K
通讯作者：
Tajima, K
影响因子：
5.1
作者：
SASAKI, S;HORACSEK, M;KESTELOOT, H
通讯作者：
KESTELOOT, H
影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
影响因子：
8.3
作者：
Iso, H;Sato, S;Shimamoto, T
通讯作者：
Shimamoto, T