Diet quality is associated with circulating C-reactive protein but not irisin levels in humans.
Diet quality is associated with circulating C-reactive protein but not irisin levels in humans.
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DOI：
10.1016/j.metabol.2013.10.011
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发表时间：
2014-02
影响因子：
9.8
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
--
作者：
Park, Kyung Hee;Zaichenko, Lesya;Peter, Patricia;Davis, Cynthia R.;Crowell, Judith A.;Mantzoros, Christos S.
坚持健康饮食已被证明可以减少肥胖和相关合并症的发生率。c反应蛋白（CRP）是一种公认的炎症标志物，鸢尾素最近被发现是一种可能在能量调节和肥胖中发挥作用的分子，但饮食是否会改变鸢尾素的水平尚不清楚。我们的目的是研究循环鸢尾素、瘦素和CRP水平与饮食数量和质量之间的关系，使用替代健康饮食指数（AHEI）和替代地中海饮食评分（aMED）。该研究评估了2009年至2011年间151名参与者的饮食数据和生物标志物水平（男性71人，女性80人，35岁以上，肥胖43.7%）。AHEI和aMED分数是根据自填的110项食物频率问卷的数据计算得出的，该问卷估计了过去一年中通常的营养摄入量。研究人员评估了禁食后饮食量、质量、身体组成（通过生物电阻抗）和生物标志物水平（包括鸢尾素、瘦素和CRP）之间的横断面相关性。CRP与AHEI呈负相关（r = - 0.34），与aMED呈负相关（r = - 0.31），而鸢尾素与AHEI呈负相关（r = - 0.34）。鸢尾素与BMI （r = 0.22）、脂肪量（r = 0.21）、腰围（r = 0.24）、腰臀比（r = 0.20）、瘦素（r = 0.32）、CRP （r = 0.25）呈正相关。AHEI得分最高的参与者往往鸢尾素浓度低11.6%（趋势P =0.09），但在调整潜在混杂因素后，它们并不显著。在多变量模型中，较好的饮食质量与较低的CRP浓度相关（趋势P =0.02）。碳水化合物的能量百分比与CRP呈负相关。与CRP不同，鸢尾素与饮食质量或数量无关。
Adherence to a healthy diet has been shown to decrease the incidence of obesity and associated comorbidities. C-reactive protein (CRP) is an established inflammatory marker and irisin was recently identified as a molecule which may play a role in energy regulation and obesity but whether diet alters irisin levels remains unknown. We aimed to investigate the association between circulating irisin, leptin, and CRP levels and dietary quantity and quality using the Alternate Healthy Eating Index (AHEI) and the Alternate Mediterranean Diet Score (aMED). The study evaluated dietary data and biomarker levels of 151 participants between 2009 and 2011 (71 male vs. 80 female, over 35 years old, obese 43.7%). AHEI and aMED scores were calculated based on data derived from self-administered 110-item food-frequency questionnaires estimating usual nutrient intake over the past year. Cross-sectional associations between dietary quantity, quality, body composition by bioelectric impedance, and biomarker levels including irisin, leptin, and CRP after fasting were assessed. CRP, but not irisin, was negatively correlated with AHEI (r = −0.34) and aMED (r = −0.31). Irisin was positively correlated with BMI (r = 0.22), fat mass (r = 0.21), waist circumference (r = 0.24), waist-hip ratio (r = 0.20), leptin (r = 0.32), and CRP (r = 0.25). Participants with the highest AHEI scores tended to have 11.6% lower concentrations of irisin (P for trend =0.09), but they were not significant after adjustment for potential confounders. Better diet quality was associated with lower CRP concentrations (P for trend=0.02) in multivariate model. Percentage of energy from carbohydrate was inversely associated with CRP. Unlike CRP, irisin is not associated with dietary quality or quantity.
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