Densonucleosis viruses ('densoviruses') for mosquito and pathogen control.

Densonucleosis viruses ('densoviruses') for mosquito and pathogen control.
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DOI:
10.1016/j.cois.2018.05.009
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发表时间:
2018-08
影响因子:
5.3
通讯作者:
Rasgon JL
Rasgon JL
中科院分区:
农林科学2区
文献类型:
--
作者:
Johnson RM;Rasgon JL

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面对日益增加的杀虫剂抗性,长期以来一直建议将蚊子特异性病毒如浓核病毒(“浓核病毒”)作为替代的蚊子控制剂。浓核病毒具有很强的物种特异性,已发现可感染许多重要的蚊子物种。虽然一些菌株是高致病性的,但其他菌株更良性。浓核病毒已被提出作为一种通过致病性相互作用减少蚊子种群的方法,但遗传策略,如病毒的副作用提供了新的方法。作为小的单链DNA病毒,浓核病毒可以容易地进行基因修饰以表达基因或非编码RNA。越来越多的文献和各种技术已经显示出使用浓核病毒控制蚊子或蚊媒病原体的潜力,以及浓核病毒作为了解蚊子生物学的分子工具的有用性。
Mosquito specific viruses such as densonucleosis viruses (“densoviruses”) have long been suggested as alternative mosquito control agents in the face of increasing insecticide resistance. Densoviruses are very species-specific and have been found to infect many important mosquito species. While some strains are highly pathogenic, other strains are more benign. Densoviruses have been proposed as a way to reduce mosquito populations through pathogenic interactions, but genetic strategies such as viral paratrangenesis offer new approaches. As small single-stranded DNA viruses, densoviruses can be easily genetically modified for the expression of genes or non-coding RNAs. A growing literature and variety of techniques have shown the potential for the use of densoviruses in the control of mosquitoes or mosquito-borne pathogens as well as the usefulness of densoviruses as molecular tools for understanding mosquito biology.
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