A preformed scleral search coil for measuring mouse eye movements.

A preformed scleral search coil for measuring mouse eye movements.
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DOI:
10.1016/j.jneumeth.2010.08.023
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发表时间:
2010-10-30
影响因子:
3
通讯作者:
Yarno, John
Yarno, John
中科院分区:
医学4区
文献类型:
--
作者:
Kaneko, Chris R. S.;Rosenfeld, Sam;Fontaine, Ethan;Markov, Alex;Phillips, James O.;Yarno, John

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小鼠是利用遗传操作技术研究病理和正常生理和行为基础的极好对象;然而,对相关表型的行为分析往往是有限的。为了提高前庭功能重复测量的准确性和特异性,我们开发了一种微型隐形眼镜巩膜搜索线圈来测量小鼠的眼球运动。我们描述了物理属性,并通过测量正常小鼠的前庭-眼睛反应来证明其功能。在小鼠的病理和功能障碍模型中,这种线圈应该可以极大地提高前庭功能障碍的敏感性和记录,同时允许对大量的受试者进行筛选。
Mice are excellent subjects for use of genetic-manipulation techniques to study the basis of pathological and normal physiology and behavior; however behavioral analyses of associated phenotypes is often limited. To improve the accuracy and specificity of repeated measurements of vestibular function, we developed a miniaturized, contact-lens scleral search coil to measure mouse eye movements. We describe the physical attributes and document its functionality by measuring vestibulo-ocular responses in normal mice. This coil should greatly improve the sensitivity and documentation of vestibular dysfunction in mouse models of pathology and dysfunction while allowing screening of significant numbers of subjects.
DOI: 10.1016/s0165-0270(00)00218-1
发表时间: 2000-06-30
影响因子: 3
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