Nondestructive monitoring of the repair of enamel artificial lesions by an acidic remineralization model using polarization-sensitive optical coherence tomography.
Nondestructive monitoring of the repair of enamel artificial lesions by an acidic remineralization model using polarization-sensitive optical coherence tomography.
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DOI：
10.1016/j.dental.2011.11.020
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发表时间：
2012-05
期刊：
影响因子：
5
通讯作者：
Fried, Daniel
中科院分区：
文献类型：
--
作者：
Kang, Hobin;Darling, Cynthia L.;Fried, Daniel
关键词：
由于新的矿物质沉积在最外层，向病变内部的扩散受到抑制，因此很难完全再矿化。在以往利用偏振敏感光学相干层析成像（PS-OCT）进行的再矿化研究中，采用了两种再矿化模型，在这两种模型中，矿物在最外层优先沉积。在这项研究中，我们尝试使用酸性再矿化模型对整个病变进行再矿化，并证明这种再矿化可以使用PS-OCT进行监测。将深度约100-150µm的人工病变暴露于酸性再矿化方案中，并使用PS-OCT测量再矿化前后病变的综合反射率。自动整合程序在评估再矿化后病变区域的整合反射率方面效果良好。虽然有高度的再矿化，但病变体仍有不完全的再矿化。这项研究表明，PS-OCT可以用于非破坏性地测量暴露于酸性再矿化模型后病变结构和严重程度的变化。该研究还表明，即使存在弱反射表面区，自动算法也可用于评估病变严重程度。
It is difficult to completely remineralize carious lesions because diffusion into the interior of the lesion is inhibited as new mineral is deposited in the outermost layers. In previous remineralization studies employing polarization sensitive optical coherence tomography (PS-OCT), two models of remineralization were employed and in both models there was preferential deposition of mineral in the outer most layer. In this study we attempted to remineralize the entire lesion using an acidic remineralization model and demonstrate that this remineralization can be monitored using PS-OCT. Artificial lesions approximately 100–150 µm in-depth were exposed to an acidic remineralization regimen and the integrated reflectivity from the lesions was measured before and after remineralization using PS-OCT. Automated integration routines worked well for assessing the integrated reflectivity for the lesion areas after remineralization. Although there was a high degree of remineralization, there was still incomplete remineralization of the body of the lesion. This study demonstrated that PS-OCT can be used to non-destructively measure changes in lesion structure and severity upon exposure to an acidic remineralization model. This study also demonstrated that automated algorithms can be used to assess the lesion severity even with the presence of a weakly reflective surface zone.
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