Altered neural connectivity in adult female rats exposed to early life social stress.
Altered neural connectivity in adult female rats exposed to early life social stress.
复制标题
暴露于早期生活压力的成年雌性大鼠的神经连通性改变了。
DOI：
10.1016/j.bbr.2016.08.051
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发表时间：
2017-01-01
影响因子：
2.7
通讯作者：
King JA
中科院分区：
文献类型：
--
作者：
Nephew BC;Huang W;Poirier GL;Payne L;King JA
各种神经解剖学技术的使用使人们更好地了解了压力对精神健康的不利影响。一个特别有价值的最新进展是临床研究中静息状态功能连接(RSFC)的发展。本研究探讨了成年雌性F1大鼠早期慢性社会应激(ECSS)的变化。在F0母笼子里每天引入一只新的雄性入侵者，而F1仔鼠在笼子里。这个针对F1动物的ECSS包括来自其F0级母亲的抑郁的母爱，以及他们的F0级母亲和入侵的雄性动物之间的冲突。对暴露于ECSS的成年雌性与对照雌性的功能连接性数据的分析显示，边缘系统和奖励系统、突显和内省的社会情感网络以及几个额外的应激和社会行为相关核团发生了广泛的变化。在前额叶皮质、伏隔核、海马体感觉皮质中发现了连接的实质性变化。目前的啮齿动物RSFC数据支持这一假说，即暴露在早期社会应激对许多社会行为、应激和抑郁相关脑核的神经连接具有长期影响。未来有意识的啮齿动物RSFC研究可以建立在先前对早期生活应激的神经解剖学研究产生的丰富数据的基础上，并在开发新的预防措施和治疗方法方面加强动物和人类fMRI研究之间的翻译连接。
The use of a variety of neuroanatomical techniques has led to a greater understanding of the adverse effects of stress on psychiatric health. One recent advance that has been particularly valuable is the development of resting state functional connectivity (RSFC) in clinical studies. The current study investigates changes in RSFC in F1 adult female rats exposed to the early life chronic social stress (ECSS) of the daily introduction of a novel male intruder to the cage of their F0 mothers while the F1 pups are in the cage. This ECSS for the F1 animals consists of depressed maternal care from their F0 mothers and exposure to conflict between their F0 mothers and intruder males. Analyses of the functional connectivity data in ECSS exposed adult females versus control females reveal broad changes in the limbic and reward systems, the salience and introspective socioaffective networks, and several additional stress and social behavior associated nuclei. Substantial changes in connectivity were found in the prefrontal cortex, nucleus accumbens, hippocampus, and somatosensory cortex. The current rodent RSFC data support the hypothesis that the exposure to early life social stress has long term effects on neural connectivity in numerous social behavior, stress, and depression relevant brain nuclei. Future conscious rodent RSFC studies can build on the wealth of data generated from previous neuroanatomical studies of early life stress and enhance translational connectivity between animal and human fMRI studies in the development of novel preventative measures and treatments.
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