Prenatal health behaviours as predictors of human placental lactogen levels.
Prenatal health behaviours as predictors of human placental lactogen levels.
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DOI：
10.3389/fendo.2022.946539
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
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胎盘催乳素（hPL）是妊娠的关键激素，负责诱导对成功妊娠至关重要的母体适应。低水平的胎盘催乳素与低出生体重以及母亲抑郁和焦虑的症状有关。据报道，在体重指数（BMI）较高的妇女中，胎盘催乳素水平较低，但目前尚不清楚产前健康行为是否能预测hPL水平，或者hPL是否与婴儿体重结果相关。这项研究利用了来自南威尔士威尔士的纵向增长队列的数据。参与者在术前预约时被招募进行择期剖腹产。本研究纳入了招募、分娩后和12个月随访的数据。248名参与者可获得母体血清hPL的测量结果。分析包括未校正和校正的线性和二元回归。未经调整的产前吸烟和注重健康的饮食模式与hPL水平相关，但在调整预订时的BMI、威尔士多重剥夺指数（WMD）评分和胎盘重量后，这一点消失了。当按母亲在预订时的BMI分层时，健康意识饮食模式仍然与健康BMI女性的hPL水平增加相关（p= 0.024，B= 0.59）。95%CI = 0.08，1.11）。当调整广泛的混杂因素时，母体hPL也与增加的自定义出生体重百分位数（CBWC）相关（p= 0.014，B=1.64）。95%CI = 0.33，2.94）和大于胎龄分娩的几率增加（p=<0.001，Exp（B）=1.42. 95%CI = 1.17，1.72）。这项研究发现，在健康BMI的女性中，怀孕期间食用健康意识饮食模式与hPL增加有关。此外，较高的hPL水平与CBWC增加和分娩大于胎龄儿的几率增加相关。这改善了目前围绕hPL在这些领域的性质的有限证据。
Placental lactogen (hPL) is a key hormone of pregnancy responsible for inducing maternal adaptations critical for a successful pregnancy. Low levels of placental lactogen have been associated with lower birth weight as well as symptoms of maternal depression and anxiety. Lower placental lactogen has been reported in women with higher body mass index (BMI) but it is unclear whether prenatal health behaviours predict hPL levels or if hPL is associated with infant weight outcomes. This study utilised data from the longitudinal Grown in Wales cohort, based in South Wales. Participants were recruited at the pre-surgical appointment for an elective caesarean section. This study incorporates data from recruitment, post-delivery and a 12 month follow-up. Measures of maternal serum hPL were available for 248 participants. Analysis included unadjusted and adjusted linear and binary regression. Unadjusted, prenatal smoking and a Health Conscious dietary pattern were associated with hPL levels, however this was lost on adjustment for BMI at booking, Welsh Index of Multiple Deprivation (WIMD) score and placental weight. When stratified by maternal BMI at booking, a Health Conscious dietary pattern remained associated with increased hPL levels in women with a healthy BMI (p=.024, B=.59. 95% CI=.08,1.11) following adjustment for WIMD score and placental weight. When adjusted for a wide range of confounders, maternal hPL was also associated with increased custom birthweight centiles (CBWC) (p=.014, B=1.64. 95% CI=.33,2.94) and increased odds of large for gestational age deliveries (p=<.001, Exp(B)=1.42. 95% CI=1.17,1.72). This study identified that consuming a Health Conscious dietary pattern in pregnancy was associated with increased hPL, within women of a healthy BMI. Moreover, higher hPL levels were associated with increased CBWC and increased odds of delivering a large for gestational age infant. This improves the current limited evidence surrounding the nature of hPL in these areas.
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