Does acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: a comparative study of true and sham acupuncture using functional magnetic resonance imaging.
Does acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: a comparative study of true and sham acupuncture using functional magnetic resonance imaging.
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DOI：
10.5056/jnm.2012.18.3.305
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发表时间：
2012-07
影响因子：
3.4
通讯作者：
Sung JJ
中科院分区：
文献类型：
--
作者：
Chu WC;Wu JC;Yew DT;Zhang L;Shi L;Yeung DK;Wang D;Tong RK;Chan Y;Lao L;Leung PC;Berman BM;Sung JJ
肠易激综合征（IBS）患者的特征是异常的中枢处理与改变的大脑激活内脏伤害性信号的反应。电针对IBS患者的影响尚不清楚。本研究采用随机化假对照模型，研究电针对IBS患者在伤害性直肠扩张期间脑激活的影响。将30例IBS腹泻患者随机分为真电针组和假电针组。在以下时间点进行功能性MRI以评估脑激活：（1）基线时仅存在直肠扩张，（2）应用EA期间的直肠扩张，（3）停止EA后的直肠扩张和（4）单独EA而无直肠扩张。采用SPM 5程序进行各组比较。在基线时，直肠扩张诱导前扣带皮层、前额叶皮层、丘脑、颞区和小脑的显著激活。在电针期间和之后，在两组的前扣带皮层、双侧前额叶皮层、丘脑、颞区和右侧丘脑中观察到大脑激活从基线增加。然而，与假针灸相比，真正的电针导致右脑岛以及丘脑枕核和内侧核的激活显着更高。我们推测针刺可能通过两种作用对IBS的疼痛调节产生潜在作用：（1）调节丘脑腹侧5-羟色胺通路;（2）通过丘脑枕核和内侧核的上行通路调节高级皮质中枢的情绪和情感。
Patients with irritable bowel syndrome (IBS) are characterized by abnormal central processing with altered brain activation in response to visceral nociceptive signals. The effect of electroacupuncture (EA) on IBS patients is unclear. The study is set to study the effect of EA on brain activation during noxious rectal distension in IBS patients using a randomized sham-controlled model. Thirty IBS-diarrhea patients were randomized to true electroacupuncture or sham acupuncture. Functional MRI was performed to evaluate cerebral activation at the following time points: (1) baseline when there was rectal distension only, (2) rectal distension during application of EA, (3) rectal distension after cessation of EA and (4) EA alone with no rectal distension. Group comparison was made under each condition using SPM5 program. Rectal distension induced significant activation of the anterior cingulated cortex, prefrontal cortex, thalamus, temporal regions and cerebellum at baseline. During and immediately after EA, increased cerebral activation from baseline was observed in the anterior cingulated cortex, bilateral prefrontal cortex, thalamus, temporal regions and right insula in both groups. However, true electroacupuncture led to significantly higher activation at right insula, as well as pulvinar and medial nucleus of the thalamus when compared to sham acupuncture. We postulate that acupuncture might have the potential effect of pain modulation in IBS by 2 actions: (1) modulation of serotonin pathway at insula and (2) modulation of mood and affection in higher cortical center via ascending pathway at the pulvinar and medial nucleus of the thalamus.
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影响因子：
9.8
作者：
Lembo, Anthony J.;Conboy, Lisa;Kelley, John M.;Schnyer, Rosa S.;McManus, Claire A.;Quilty, Mary T.;Kerr, Catherine E.;Drossman, Doug;Jacobson, Eric E.;Davis, Roger B.;Kaptchuk, Ted J.
通讯作者：
Kaptchuk, Ted J.
影响因子：
4.8
作者：
Napadow, V;Makris, N;Hui, KKS
通讯作者：
Hui, KKS
影响因子：
3.2
作者：
Fireman, Z;Segal, A;Carasso, R
通讯作者：
Carasso, R
DOI：
10.1089/acm.1995.1.257
发表时间：
1995-01-01
期刊：
Journal of alternative and complementary medicine (New York, N.Y.)
影响因子：
--
作者：
Lao, L;Wong, R H;Wynn, R L
通讯作者：
Wynn, R L
影响因子：
3.6
作者：
Lao, LX;Zhang, G;Berman, BM
通讯作者：
Berman, BM