A Subdural Bioelectronic Implant to Record Electrical Activity from the Spinal Cord in Freely Moving Rats.
A Subdural Bioelectronic Implant to Record Electrical Activity from the Spinal Cord in Freely Moving Rats.
复制标题
记录自由活动大鼠脊髓电活动的硬膜下生物电子植入物。
DOI：
10.1002/advs.202105913
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发表时间：
2022-07
期刊：
影响因子：
15.1
通讯作者：
Svirskis, Darren
中科院分区：
文献类型：
--
作者：
Harland, Bruce;Aqrawe, Zaid;Vomero, Maria;Boehler, Christian;Cheah, Ernest;Raos, Brad;Asplund, Maria;O'Carroll, Simon J.;Svirskis, Darren
关键词：
生物电子装置已在与神经组织的界面处发现用途，以研究和治疗神经系统病症。在这里，一个非常薄的灵活的生物电子植入物插入沿着大鼠胸脊髓直接接触和顺应脊髓背侧表面的发展和表征。对后肢功能没有负面影响，脊髓的体积或形状也没有任何变化。生物电子植入物在大鼠中保持12周的时间。第一次硬脑膜下记录的脊髓活动在自由移动的动物;大鼠插入通过记录电缆，并允许自由的行为和移动在一个升高的平台。记录包含多个不同的电压波形空间定位到各个电极。该设备具有监测脊髓损伤后电信号的巨大潜力，未来，该植入物将有助于识别脊髓损伤和恢复中的生物标志物，同时能够提供局部电化学治疗。一个非常薄的灵活的生物电子植入物，插入沿着大鼠胸脊髓被证明。尽管环境高度敏感，但在12周内对后肢功能没有负面影响。该植入物提供了直接和连续的进入脊髓，允许从自由行为的动物报告脊髓活动的第一个电记录。
Bioelectronic devices have found use at the interface with neural tissue to investigate and treat nervous system disorders. Here, the development and characterization of a very thin flexible bioelectronic implant inserted along the thoracic spinal cord in rats directly in contact with and conformable to the dorsal surface of the spinal cord are presented. There is no negative impact on hind‐limb functionality nor any change in the volume or shape of the spinal cord. The bioelectronic implant is maintained in rats for a period of 12 weeks. The first subdural recordings of spinal cord activity in freely moving animals are presented; rats are plugged in via a recording cable and allowed to freely behave and move around on a raised platform. Recordings contained multiple distinct voltage waveforms spatially localize to individual electrodes. This device has great potential to monitor electrical signaling in the spinal cord after an injury and in the future, this implant will facilitate the identification of biomarkers in spinal cord injury and recovery, while enabling the delivery of localized electroceutical and chemical treatments. A very thin flexible bioelectronic implant that is inserted along the thoracic spinal cord in rats is demonstrated. Despite the highly sensitive environment, there is no negative impact on hind‐limb functionality over 12 weeks. The implant provides direct and continuous access to the spinal cord, allowing the first electrical recordings of spinal activity to be reported from freely behaving animals.
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