Startle to neutral, not negative stimuli: A neurophysiological correlate of behavioral inhibition in young children.
Startle to neutral, not negative stimuli: A neurophysiological correlate of behavioral inhibition in young children.
复制标题
DOI：
10.1002/dev.22120
复制
发表时间：
2021-07
影响因子：
2.2
通讯作者：
Fitzgerald KD
中科院分区：
文献类型：
--
作者：
Premo JE;Mannella KA;Duval ER;Liu Y;Morrison CL;Moser JS;Muzik M;Rosenblum KL;Fitzgerald KD
作为焦虑风险的假定生物标志物，与中性情绪调节相比，成年人的惊吓反应通常会因负面情绪而增强，但在儿童中的研究仍然不足。为了确定中性、消极和正价情绪条件在多大程度上调节生命早期的惊吓反应，我们使用儿童友好的电影范式来改变 64 名 4 至 7 岁儿童在惊吓诱导期间的情绪。评估了情绪调节惊吓与家长报告的焦虑症状严重程度和儿童行为抑制（焦虑问题的危险因素）之间的关系。分析显示，与中性电影片段相比，负面电影片段的惊吓程度没有差异。相比之下，消极和中性条件下的惊吓程度都大于积极条件下的惊吓程度。中性状态下较大的惊吓幅度与较高水平的儿童行为抑制（BI）相关。这些结果与幼儿惊吓反应可能不成熟的情况相一致，并表明在情绪更加模糊、中性的条件下的惊吓幅度可以作为焦虑风险的早期生物标志物。
A putative biomarker of anxiety risk, the startle response is typically enhanced by negative compared to neutral emotion modulation in adults, but remains understudied in children. To determine the extent to which neutral, negative, and positively valenced emotional conditions modulate startle response in early life, a child-friendly film paradigm was used to vary emotion across these conditions during startle induction in sixty-four 4- to 7-year-old children. Association of emotion-modulated startle with parent-reported anxiety symptom severity and child behavioral inhibition, a risk factor for anxiety problems, were assessed. Analyses revealed no difference in startle magnitude during negative compared to neutral film clips. By contrast, startle during both negative and neutral conditions was greater than startle during the positive condition. Larger startle magnitude during the neutral condition associated with higher levels of child behavioral inhibition (BI). These results are consistent with possible immaturity of startle response in young children, and suggest that startle amplitude in more emotionally ambiguous, neutral conditions could serve as an early biomarker for anxiety risk.
登录
查看更多内容
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Khemka S;Tzovara A;Gerster S;Quednow BB;Bach DR
通讯作者：
Bach DR
影响因子：
4.2
作者：
Blackford, Jennifer Urbano;Avery, Suzanne N.;Zald, David H.
通讯作者：
Zald, David H.
影响因子：
4.6
作者：
KAGAN, J;REZNICK, JS;JOHNSON, MO
通讯作者：
JOHNSON, MO
影响因子：
10.6
作者：
Grillon, C
通讯作者：
Grillon, C