A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations.
A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations.
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三种不同病变部位脑卒中后抑郁的脑功能网络研究
DOI：
10.1038/s41598-017-14675-4
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发表时间：
2017-11-01
影响因子：
4.6
通讯作者：
Wu W
中科院分区：
文献类型：
--
作者：
Shi Y;Zeng Y;Wu L;Liu Z;Zhang S;Yang J;Wu W
研究脑卒中后抑郁的发生机制是提高脑卒中后抑郁治疗水平的重要途径。然而，功能磁共振成像（fMRI）的研究结果并未完全支持PSD的功能脑网络。本研究的目的是探讨PSD在三种不同病变中的脑反应。三个PSD亚组的大脑反应相似。然而，每个亚组都有自己的大脑网络特征。在颞叶亚组中，右丘脑中心性度（DC）值增加，与其他两个亚组不同。在额叶亚组中，左背外侧前额叶皮层、尾状回和中央后回的DC值增加，与其他两个亚组不同。PSD的血流动力学反应表明PSD具有类似的情绪网络活动，其中负性网络通过边缘系统和默认模式网络实现其功能。不同病变部位的脑网络具有不同的特征。损伤部位的神经功能、大脑的代偿机制、大脑的完整性和局部性机制是影响个体情绪网络的重要因素。
Research on the mechanism of post stroke depression (PSD) is the key way to improve the treatment of PSD. However, the functional brain network of PSD has not been entirely supported by the results of functional magnetic resonance imaging (fMRI) studies. The aims of this study are to investigate the brain response of PSD in three different lesions. The brain responses of the three PSD subgroups were similar. However, each subgroup had its own characteristics of the brain network. In the temporal lobe subgroup, the right thalamus had increased degree centrality (DC) values which were different from the other two subgroups. In the frontal lobe subgroup, the left dorsolateral prefrontal cortex, caudate, and postcentral gyrus had increased DC values which were different from the other two subgroups. The hemodynamic response of PSD indicates that PSD has activities of similar emotional networks, of which the negative network realizes its function through the limbic system and default mode network. The brain network has unique characteristics for different lesion locations. The neurological function of the lesion location, the compensatory mechanism of the brain, and the mechanism of integrity and locality of the brain are the important factors in the individual emotional network.
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影响因子：
4.3
作者：
Otti, Alexander;Guendel, Harald;Noll-Hussong, Michael
通讯作者：
Noll-Hussong, Michael
DOI：
10.5535/arm.2016.40.3.412
发表时间：
2016-06
期刊：
Annals of rehabilitation medicine
影响因子：
--
作者：
Koh DJ;Kim NY;Kim YW
通讯作者：
Kim YW
影响因子：
2.6
作者：
Jackson, PL;Brunet, E;Decety, J
通讯作者：
Decety, J
DOI：
10.1101/lm.028266.112
发表时间：
2012-12-21
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Cross L;Brown MW;Aggleton JP;Warburton EC
通讯作者：
Warburton EC
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.