Reduced natural oscillatory frequency of frontal thalamocortical circuits in schizophrenia.
Reduced natural oscillatory frequency of frontal thalamocortical circuits in schizophrenia.
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DOI：
10.1001/archgenpsychiatry.2012.147
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发表时间：
2012-08
影响因子：
--
通讯作者：
Tononi, Giulio
中科院分区：
文献类型：
--
作者：
Ferrarelli, Fabio;Sarasso, Simone;Guller, Yelena;Riedner, Brady A.;Peterson, Michael J.;Bellesi, Michele;Massimini, Marcello;Postle, Bradley R.;Tononi, Giulio
来自电生理学研究的聚合证据表明，在精神分裂症患者中，脑电快速额叶振荡减少。目前尚不清楚这种减少是否反映了潜在皮质/丘脑皮质回路的内在缺陷，以及这种缺陷是否仅限于额叶区域。最近对健康人的电生理学研究证实，当受到干扰时，不同的大脑区域会以特定的、内在产生的主导频率--自然频率--振荡。目的：评估精神分裂症患者和健康对照组的顶后皮质、运动前皮质、前额叶皮质的自然频率。在经颅磁刺激(TMS)的四个皮质区域进行高密度脑电(HD-EEG)记录。精神分裂症组和健康对照组比较了TMS诱发的几个脑电振荡参数，包括同步性、幅度和自然频率。威斯康星大学麦迪逊分校威斯康星精神病学研究所和临床中心，20名精神分裂症患者和20名年龄匹配的健康对照。HD-EEG测量TMS诱发的四个皮质区域的活动，阳性和阴性症状量表(PANSS)，以及在两个计算机化任务中的操作分数(反应时间，准确性)：单词记忆(CPW)和面部记忆(CPF)测试。与健康对照组相比，精神分裂症患者额叶/前额叶区域的自然频率减慢(运动区平均减少2赫兹，前额叶皮质减少近10赫兹)。精神分裂症患者的前额叶自然频率慢于任何健康对照组，且与阳性PANSS评分和CPW中的反应时呈正相关。这些发现表明，精神分裂症患者额叶皮质/丘脑皮质回路的自然频率有内在的减慢，这种减慢在顶叶区域不存在，前额叶自然频率可以预测精神分裂症的一些症状以及认知功能障碍。
Converging evidence from electrophysiological studies suggests that in individuals with schizophrenia EEG fast frontal oscillations are reduced. It is still unclear whether this reduction reflects an intrinsic deficit of underlying cortical/thalamo-cortical circuits, and whether this deficit is specific for frontal regions. Recent electrophysiological studies in healthy individuals have established that, when perturbed, different brain regions oscillate at a specific, intrinsically generated dominant frequency, the natural frequency. To assess the natural frequency of posterior parietal, motor, premotor, and prefrontal cortices, in schizophrenic and healthy controls. High-density electroencephalogram (Hd-EEG) recordings during Transcranial Magnetic Stimulation (TMS) of four cortical areas were performed. Several TMS-evoked EEG oscillation parameters, including synchronization, amplitude, and natural frequency were compared across the schizophrenia and healthy control groups. Wisconsin Psychiatric Institute & Clinic, University of Wisconsin-Madison Twenty patients with schizophrenia and twenty age-matched healthy controls. Hd-EEG measurements of TMS-evoked activity in four cortical areas, the positive and negative syndrome scale (PANSS), and performance scores (reaction time, accuracy) in two computerized tasks: the word memory (CPW) and the facial memory (CPF) tests. Schizophrenia patients showed a slowing in the natural frequency of frontal/prefrontal regions compared to healthy controls (from an average of 2 Hz decrease for the motor area, to almost 10 Hz for the prefrontal cortex). The prefrontal natural frequency of individuals with schizophrenia was slower than in any healthy comparison subject, and correlated with both positive PANSS scores and reaction time in the CPW. These findings suggest that patients with schizophrenia have an intrinsic slowing in the natural frequency of frontal cortical/thalamo-cortical circuits, that this slowing is not present in parietal areas, and that the prefrontal natural frequency can predict some of the symptoms as well as the cognitive dysfunctions of schizophrenia.
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影响因子：
4.8
作者：
Henseler, Ilona;Falkai, Peter;Gruber, Oliver
通讯作者：
Gruber, Oliver
影响因子：
10.6
作者：
Carter, Cameron S.;Barch, Deanna M.;Bullmore, Edward T.;Breiling, James;Buchanan, Robert W.;Butler, Pamela;Cohen, Jonathan D.;Geyer, Mark;Gollub, Randy;Green, Michael F.;Jaeger, Judith;Krystal, John H.;Moore, Holly;Nuechterlein, Keith;Robbins, Trevor;Silverstein, Steven;Smith, Edward E.;Strauss, Milton;Wykes, Til
通讯作者：
Wykes, Til
影响因子：
6.6
作者：
Ferrarelli, Fabio;Tononi, Giulio
通讯作者：
Tononi, Giulio
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
Carter, C. S.
影响因子：
17.7
作者：
Ford, Judith M.;Roach, Brian J.;Mathalon, Daniel H.
通讯作者：
Mathalon, Daniel H.