Addiction related alteration in resting-state brain connectivity.
Addiction related alteration in resting-state brain connectivity.
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与成瘾相关的静息态大脑连接的改变
DOI：
10.1016/j.neuroimage.2009.08.037
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Zhang, Da-Ren
中科院分区：
文献类型：
--
作者：
Ma, Ning;Liu, Ying;Li, Nan;Wang, Chang-Xin;Zhang, Hao;Jiang, Xiao-Feng;Xu, Hu-Sheng;Fu, Xian-Ming;Hu, Xiaoping;Zhang, Da-Ren
人们普遍认为，成瘾性药物的使用与使用者大脑中的异常功能组织有关。本研究旨在通过功能性磁共振成像（fMRI）测量静息态功能连接来识别与成瘾有关的脑网络中的这种类型的异常。利用14名慢性海洛因使用者（其中12名正在接受美沙酮治疗）和13名非成瘾对照者在静息状态下获得的fMRI数据，我们采用基于种子的相关分析研究了成瘾相关回路中涉及成瘾的区域之间的功能连接变化。与对照组相比，慢性海洛因依赖者的中脑核与腹侧/喙侧前扣带皮层（ACC）、眶额皮层（OFC）、杏仁核与OFC之间的功能连接增加;以及减少前额叶皮层和眶额皮层之间的功能连接，和ACC。这些观察到的改变休息-状态功能连接表明成瘾大脑中的功能组织异常，并可能提供额外的证据支持强调增强的成瘾理论药物及其相关线索的显著性价值，但在成瘾状态下削弱了认知控制。
It is widely accepted that addictive drug use is related to abnormal functional organization in the user’s brain. The present study aimed to identify this type of abnormality within the brain networks implicated in addiction by resting-state functional connectivity measured with functional magnetic resonance imaging (fMRI). With fMRI data acquired during resting state from 14 chronic heroin users (12 of whom were being treated with methadone) and 13 non-addicted controls, we investigated the addiction related alteration in functional connectivity between the regions in the circuits implicated in addiction with seed-based correlation analysis. Compared with controls, chronic heroin users showed increased functional connectivity between nucleus accumbens and ventral/rostral anterior cingulate cortex (ACC), and orbital frontal cortex (OFC), between amygdala and OFC; and reduced functional connectivity between prefrontal cortex and OFC, and ACC. These observations of altered resting-state functional connectivity suggested abnormal functional organization in the addicted brain and may provide additional evidence supporting the theory of addiction that emphasizes enhanced salience value of a drug and its related cues but weakened cognitive control in the addictive state.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
2.5
作者：
Auer, Dorothee P.
通讯作者：
Auer, Dorothee P.
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
3.7
作者：
Elliott, R.;Agnew, Z.;Deakin, J. F. W.
通讯作者：
Deakin, J. F. W.