Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention.
Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention.
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DOI：
10.1016/j.tins.2020.08.001
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发表时间：
2020-10
影响因子：
15.9
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Luby JL;Baram TZ;Rogers CE;Barch DM
人类大脑的发育受到早期生活经历的影响，特别是在敏感时期，对认知和情感结果产生影响。了解这些经历（包括逆境、创伤和丰富）的时间和性质如何控制它们对大脑组织的影响，对于在生命早期利用关键的环境因素来促进大脑发育至关重要。在这里，我们综合了人类和动物研究的发现，重点关注敏感期及其区域和回路的特异性，并强调了这种跨物种方法的挑战和力量，为优化发育中儿童的认知和情感健康的“下一步”提供了信息。我们建议设计神经发育优化研究项目，利用儿童早期随机增强试验，为预防和早期干预的公共卫生策略提供信息。
Human brain development is influenced by early-life experiences, particularly during sensitive periods, with impact on cognitive and emotional outcomes. Understanding how the timing and the nature of such experiences (including adversity, trauma and enrichment) governs their influence on brain organization is crucial for harnessing key environmental factors early in life to enhance brain development. Here we synthesize findings from human and animal studies focusing on sensitive periods and their regional and circuit specificity, and highlight the challenge and power of such cross-species approaches for informing the ‘next steps’ in optimizing cognitive and emotional health in developing children. We propose designs for neurodevelopmental optimization research programs utilizing randomized enhancement trials in early childhood to inform public health strategies on prevention and early intervention.
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影响因子：
6.4
作者：
Fisher PA;Frenkel TI;Noll LK;Berry M;Yockelson M
通讯作者：
Yockelson M
影响因子：
16.2
作者：
Espinosa JS;Stryker MP
通讯作者：
Stryker MP
影响因子：
3
作者：
Curley, James P.;Davidson, Stephanie;Champagne, Frances A.
通讯作者：
Champagne, Frances A.
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim
影响因子：
3.3
作者：
Goff B;Gee DG;Telzer EH;Humphreys KL;Gabard-Durnam L;Flannery J;Tottenham N
通讯作者：
Tottenham N