Classical and instrumental conditioning of eyeblink responses in Wistar-Kyoto and Sprague-Dawley rats.
Classical and instrumental conditioning of eyeblink responses in Wistar-Kyoto and Sprague-Dawley rats.
复制标题
DOI：
10.1016/j.bbr.2010.08.029
复制
发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Servatius, Richard. J.
中科院分区：
文献类型：
--
作者：
Ricart, Thomas M.;Jiao, Xilu;Pang, Kevin C. H.;Beck, Kevin D.;Servatius, Richard. J.
关键词：
焦虑易感性动物模型Wistar Kyoto （WKY）大鼠比近交系Sprague Dawley （SD）大鼠获得杠杆-按回避更快。更快的回避习得可能反映了获得线索-结果关联、反应-结果关联或两者兼而有之的内在能力。为了评估线索结果学习，采用延迟型范式（500 ms条件刺激（CS）和10 ms无条件刺激（US））比较SD大鼠和WKY大鼠经典条件眨眼反应的习得。与SD大鼠相比，WKY大鼠在延迟型训练中表现出更快的习得和更好的渐近表现。为了评估反应-结果学习，分别对SD和WKY大鼠进行控制，通过在延迟型训练中施加遗漏偶然性（发出条件反应（CR）阻止传递US）。由这些大鼠得出的美国分娩时间表成为另一组SD和WKY大鼠的训练方案，在品系内枷锁。在SD大鼠中，在给予US传递控制的大鼠和用相同的部分强化计划训练的大鼠之间，没有发现习得的差异。对照组的WKY大鼠的习得率超过了用美国演示时间表训练的大鼠。总的来说，与远交种SD大鼠相比，WKY大鼠表现出更强的经典条件反射和对强化时间表的敏感性。焦虑脆弱性，特别是抑制气质，可以追溯到预测和控制厌恶事件的主动过程。
Wistar Kyoto (WKY) rats, an animal model of anxiety vulnerability, acquire lever-press avoidance faster than outbred Sprague Dawley (SD) rats. Faster avoidance acquisition may reflect an inherent ability to acquire cue-outcome associations, response-outcome associations or both. To evaluate cue-outcome learning, acquisition of classically conditioned eyeblink response was compared in SD and WKY rats using a delay-type paradigm (500-ms conditioned stimulus (CS) coterminating with a 10-ms unconditional stimulus (US)). WKY rats demonstrated enhanced classical conditioning, with both faster acquisition and greater asymptotic performance in delay-type training than SD rats. To evaluate response-outcome learning, separate SD and WKY rats were given control over US delivery through imposition of an omission contingency into delay-type training (emitting a conditioned response (CR) prevented delivery of the US). The schedule of US delivery derived by these rats became the training regimen for a separate group of SD and WKY rats, yoked within strain. In SD rats, no differences in acquisition were detected between those given control over US delivery and those trained with the same partial reinforcement schedule. Acquisition rates of those WKY rats with control exceeded those trained with a yoked-schedule of US presentation. Collectively, WKY rats exhibit enhanced classical conditioning and sensitivity to schedules of reinforcement compared to outbred SD rats. Anxiety vulnerability, in particular inhibited temperament, may be traced to active processes in the prediction and control of aversive events.
登录
查看更多内容
影响因子：
17.7
作者：
Grillon, Christian;Lissek, Shmuel;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
3.6
作者：
Dubi, Kathrin;Rapee, Ronald M.;Schniering, Carolyn A.
通讯作者：
Schniering, Carolyn A.
影响因子：
--
作者：
HELLIGE, JB;GRANT, DA
通讯作者：
GRANT, DA
影响因子：
1.9
作者：
Bangasser, DA;Santollo, J;Shors, TJ
通讯作者：
Shors, TJ
影响因子：
3.6
作者：
Ferguson, SA;Cada, AM
通讯作者：
Cada, AM