Preliminary fMRI findings in experimentally sleep-restricted adolescents engaged in a working memory task.
Preliminary fMRI findings in experimentally sleep-restricted adolescents engaged in a working memory task.
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DOI：
10.1186/1744-9081-5-9
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发表时间：
2009-02-19
期刊：
影响因子：
--
通讯作者：
Holland SK
中科院分区：
文献类型：
--
作者：
Beebe DW;Difrancesco MW;Tlustos SJ;McNally KA;Holland SK
在这里，我们报告了一项小样本功能磁共振成像(FMRI)研究的初步结果，该研究针对健康青少年，他们在慢性睡眠限制实验的背景下完成了一项工作记忆任务。研究结果与之前对严重睡眠不足的成年人的研究结果一致。我们的数据表明，当被要求保持注意力并受到长期睡眠限制的负担时，青少年的大脑通过补偿机制做出反应，这种机制突出了与注意力相关的大脑区域的典型激活模式。具体地说，在休息良好的大脑中，在一项要求注意力的工作记忆任务中，通常活跃的区域似乎在长期睡眠限制后变得更加活跃，以维持表现。相比之下，在休息良好的大脑中，正常情况下活动受到抑制的区域在长期睡眠限制后表现出更大的抑制以维持表现。尽管样本有限，但研究结果提供了重要的可行性证据，并为未来研究长期睡眠限制对神经功能的影响、儿童和青少年睡眠限制的影响以及儿童注意力及其障碍的神经科学提供了指导。
Here we report preliminary findings from a small-sample functional magnetic resonance imaging (fMRI) study of healthy adolescents who completed a working memory task in the context of a chronic sleep restriction experiment. Findings were consistent with those previously obtained on acutely sleep-deprived adults. Our data suggest that, when asked to maintain attention and burdened by chronic sleep restriction, the adolescent brain responds via compensatory mechanisms that accentuate the typical activation patterns of attention-relevant brain regions. Specifically, it appeared that regions that are normally active during an attention-demanding working memory task in the well-rested brain became even more active to maintain performance after chronic sleep restriction. In contrast, regions in which activity is normally suppressed during such a task in the well-rested brain showed even greater suppression to maintain performance after chronic sleep restriction. Although limited by the small sample, study results provide important evidence of feasibility, as well as guidance for future research into the functional neurological effects of chronic sleep restriction in general, the effects of sleep restriction in children and adolescents, and the neuroscience of attention and its disorders in children.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
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通讯作者：
Dinges, David F.
影响因子：
5.6
作者：
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通讯作者：
Chee, Michael W. L.
影响因子：
5.3
作者：
Chee, MWL;Choo, WC
通讯作者：
Choo, WC
DOI：
10.1111/j.1469-7610.2008.01885.x
发表时间：
2008-09-01
影响因子：
7.6
作者：
Beebe, Dean W.;Fallone, Gahan;Amin, Raouf
通讯作者：
Amin, Raouf