Reliability of serum and urinary isoflavone estimates.

Reliability of serum and urinary isoflavone estimates.
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DOI:
10.3109/13547500903335927
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发表时间:
2010-03
期刊:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
影响因子:
--
通讯作者:
Bennett H
Bennett H
中科院分区:
其他
文献类型:
--
作者:
Fraser GE;Franke AA;Jaceldo-Siegl K;Bennett H

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血清或尿液生物标志物的零星摄入和半衰期短可能使血清和尿液异黄酮成为长期膳食大豆摄入量的相当不可靠的指标。在 26 名复临信徒健康研究 2 (AHS-2) 参与者中,我们获得了两次早晨空腹血清异黄酮的测量值,相隔 1-2 年。在另外 76 名受试者中,我们获得了隔夜尿液样本,以及在尿液样本采集期间的 6 次 24 小时饮食回忆。血清异黄酮的组内相关性 (ICC) 值为 0.11 (log[大豆苷元]) 和 0.28 (log[染料木黄酮])。假设相关性(真实饮食摄入量,真实尿排泄量)<0.90,表明这意味着尿估计值的 ICC 超过 0.56。正如预期的那样,前一天的大豆摄入量及其时间会影响第二天早上的血清水平。这些结果表明,早晨空腹血清异黄酮估计值无法提供长期大豆摄入量的较差指数,但隔夜尿液估计值的表现要好得多。
Sporadic intake and short half lives of serum or urinary biomarkers may make serum and urinary isoflavones quite unreliable indicators of longer-term dietary soy intake. In 26 Adventist Health Study-2 (AHS-2) participants we obtained two measures of fasting morning serum isoflavones, 1–2 years apart. In another 76 subjects we obtained an overnight urine sample, and six 24 hour dietary recalls over a period encompassing the time of the urine sample. Intra-class correlations (ICC) values for serum isoflavones were 0.11 (log[daidzein]) and 0.28 (log[genistein]). Assuming that the correlation(true dietary intake, true urinary excretion)<0.90, it is shown that this implies an ICC for urinary estimates that exceeds 0.56. As expected, the previous day’s soy intake, and its timing, influenced the next morning’s serum levels. These results suggest that fasting morning serum isoflavone estimates will provide a poor index of long-term soy intake, but that overnight urinary estimates perform much better.
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