Environmental modulation of alcohol intake in hamsters: effects of wheel running and constant light exposure.
Environmental modulation of alcohol intake in hamsters: effects of wheel running and constant light exposure.
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DOI：
10.1111/j.1530-0277.2010.01251.x
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Glass JD
中科院分区：
文献类型：
--
作者：
Hammer SB;Ruby CL;Brager AJ;Prosser RA;Glass JD
酗酒会导致昼夜节律的明显紊乱，而这些紊乱本身就能增加饮酒的冲动。昼夜节律时钟的时间是由光，以及非光的影响，如食物，社会交往，和车轮运行。我们以前曾报道，酒精显着扰乱光和非光模式的昼夜节律调节叙利亚仓鼠。作为这项工作的延伸，我们表征了车轮运行和乙醇摄入量之间的享乐相互关系，以及环境昼夜节律中断（长期暴露于恒定光照[LL]）对饮酒驱动力的影响。首先，我们测试了车轮运行对慢性自由选择消耗20%（v/v）乙醇（EtOH）溶液和水的影响。第二，研究了这种饮酒对未饮酒动物的车轮运行的影响。第三，我们评估了LL的影响，已知抑制自发活动，并导致昼夜节律中断，乙醇消耗和车轮运行行为。观察到车轮运行对EtOH摄入的抑制作用，反之亦然。暴露于LL，而不影响乙醇摄入量，诱导75%的动物的节律分裂。值得注意的是，分裂表型与低水平的乙醇消耗和偏好之前，并在整个期间的LL曝光。这些结果证明，运动可能提供一种有效的临床方法来减少EtOH的摄入量。此外，光诱导（或其他）形式的昼夜节律破坏的易感性可能会调节饮酒的驱动力。
Alcohol abuse leads to marked disruptions of circadian rhythms, and these disturbances in themselves can increase the drive to drink. Circadian clock timing is regulated by light, as well as by nonphotic influences like food, social interactions, and wheel-running. We previously reported that alcohol markedly disrupts photic and nonphotic modes of circadian rhythm regulation in Syrian hamsters. As an extension of this work, we characterize the hedonic interrelationship between wheel-running and ethanol intake and the effects of environmental circadian disruption (long-term exposure to constant light [LL]) on the drive to drink. First, we tested the effect of wheel running on chronic free-choice consumption of a 20% (v/v) ethanol (EtOH) solution and water. Second, the effect of this alcohol drinking on wheel running in alcohol-naive animals was investigated. Third, we assessed the influence of LL, known to suppress locomotor activity and cause circadian rhythm disruption, on EtOH consumption and wheel-running behavior. Inhibitory effects of wheel running on EtOH intake and vice versa were observed. Exposure to LL, while not affecting EtOH intake, induced rhythm splitting in 75% of the animals. Notably, the splitting phenotype was associated with lower levels of EtOH consumption and preference prior to, and throughout, the period of LL exposure. These results are evidence that exercise may offer an efficacious clinical approach to reducing EtOH intake. Also, predisposition for light-induced (or other) forms of circadian disruption may modulate the drive to drink.
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影响因子：
2.5
作者：
CARD, JP;MOORE, RY
通讯作者：
MOORE, RY
影响因子：
3.3
作者：
Broom, D. R.;Stensel, D. J.;Miyashita, M.
通讯作者：
Miyashita, M.
DOI：
10.1007/bf00307084
发表时间：
1972-01-01
期刊：
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE
影响因子：
--
作者：
HENDRICKSON, AE;WAGONER, N;COWAN, WM
通讯作者：
COWAN, WM
影响因子：
2.9
作者：
JOHNSON, RF;MORIN, LP;MOORE, RY
通讯作者：
MOORE, RY
影响因子：
2.7
作者：
Fonken, Laura K.;Finy, M. Sima;Nelson, Randy J.
通讯作者：
Nelson, Randy J.