Human Adolescent Phase Response Curves to Bright White Light.
Human Adolescent Phase Response Curves to Bright White Light.
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DOI：
10.1177/0748730417713423
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发表时间：
2017-08
影响因子：
3.5
通讯作者：
Eastman CI
中科院分区：
文献类型：
--
作者：
Crowley SJ;Eastman CI
年龄较大的青少年特别容易受到昼夜节律失调和睡眠限制的影响，这主要是由于上学时间较早。光可以改变昼夜节律系统，有助于减轻昼夜节律失调；然而，相位响应曲线（PRC）确定的最佳时间接受光和避光的青少年是不可用的。我们为14至17岁的青春期晚期至青春期后的青少年构建了轻prc。参与者在家中安排了8或9天的睡眠后，完成了两个平衡的5天实验室课程。每个阶段包括阶段评估，以测量在超昼夜光-暗（觉醒-睡眠）周期（2小时暗（~20勒克斯）光，2小时暗）中自由运行前后3天的暗光褪黑激素发作（DLMO）。在一个疗程中，间歇性明亮的白光（~5000勒克斯，4次20分钟曝光）与10分钟的昏暗室内光交替进行，每天一次，连续3天。在24小时内，不同参与者的光照时间各不相同。对于每个个体，对明亮光的相移进行了校正，以校正来自另一个没有明亮光的实验室会话的自由运行。一个PRC显示相对于DLMO的光启动时间相移，另一个相对于家庭睡眠相移。相位延迟移动发生在与回家就寝时间相对应的几个小时左右。相位提前发生在醒来前后的几个小时和下午晚些时候。从延迟到提前的转变发生在家庭睡眠的中点。这里提出的青少年prc提供了一个有价值的工具来确定青少年的强光时间。
Older adolescents are particularly vulnerable to circadian misalignment and sleep restriction, primarily due to early school start times. Light can shift the circadian system and could help attenuate circadian misalignment; however, a phase response curve (PRC) to determine the optimal time for receiving light and avoiding light is not available for adolescents. We constructed light PRCs for late- to post-pubertal adolescents aged 14 to 17 years. Participants completed two counterbalanced 5-day laboratory sessions after 8 or 9 days of scheduled sleep at home. Each session included phase assessments to measure the dim light melatonin onset (DLMO) before and after 3 days of free-running through an ultradian light-dark (wake-sleep) cycle (2 h dim (~20 lux) light, 2 h dark). In one session, intermittent bright white light (~5000 lux; four 20-min exposures) alternated with 10 min dim room light once per day for 3 consecutive days. The time of light varied among participants to cover the 24-h day. For each individual, the phase shift to bright light was corrected for the free-run derived from the other laboratory session with no bright light. One PRC showed phase shifts in response to light start time relative to the DLMO, and another relative to home sleep. Phase delay shifts occurred around the hours corresponding to home bedtime. Phase advances occurred during the hours surrounding wake time and later in the afternoon. The transition from delays to advances occurred at the midpoint of home sleep. The adolescent PRCs presented here provide a valuable tool to time bright light in adolescents.
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影响因子：
5.8
作者：
Crowley, Stephanie J.;Cain, Sean W.;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.
DOI：
10.1196/annals.1308.032
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Carskadon, MA;Acebo, C;Jenni, OG
通讯作者：
Jenni, OG
影响因子：
5.6
作者：
Crowley, Stephanie J.;Acebo, Christine;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.
影响因子：
4.4
作者：
Agostini, Alex;Carskadon, Mary A.;Short, Michelle A.
通讯作者：
Short, Michelle A.
影响因子：
3.7
作者：
Crowley, Stephanie J.;Van Reen, Eliza;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.